基于声表面波的微粒图案化操控技术仿真设计方法研究  

Research Progress of Patterning Manipulation of Biological Particles Based on Surface Acoustic Waves

作　　者：曹建玮 王红亮[1] CAO Jianwei;WANG Hongliang(State Key Laboratory of Dynamic Measurement Technology,North University of China,Taiyuan 030051,China)

机构地区：[1]中北大学省部共建动态测试技术国家重点实验室,山西太原030051

出　　处：《压电与声光》2024年第6期884-889,共6页Piezoelectrics & Acoustooptics

基　　金：山西省基础研究计划项目(20210302123034)。

摘　　要：基于声表面波(SAW)的微粒操控技术因具有结构简单、生物相容、非侵入、可扩展和多功能等特性而成为操纵微/纳米颗粒/细胞群的重要工具。基于此类生物医疗领域的需求设计了一种由四组均匀叉指换能器组成的SAW微粒操控器件,通过建立三维有限元模型对声表面波器件进行仿真分析并得到了多种不同的声压场图案,再使用COMSOL软件的粒子追踪模块进行仿真,验证了粒子在各种声压场下都可以排列成对应图案。该设计方法有望在组织工程、体外细胞研究、创建3D仿生组织结构等方面得到应用。Surface acoustic wave(SAW)-based manipulation of particles is an indispensable tool to manipulate micro/nanoparticle/cell populations owing to its structural simplicity,biocompatibility,non-invasiveness,scalability,and versatility.This paper presents a design method of a SAW-based particle control device containing two pairs of uniform interfingered transducers.A three-dimensional(3D)finite element model is established to simulate and analyze the SAW device,and various sound pressure field patterns are obtained.The particle tracking module of COMSOL software was used to simulate and verify that the particles can be arranged into patterns under various sound pressure field patterns.The proposed design is expected to be applied in tissue engineering,in-vitro cell research,creating 3D bionic tissue structures,and other applications.

关 键 词：声表面波 生物组装 声学操纵 微粒图案化 声辐射力 

分 类 号：TN65[电子电信—电路与系统]