医用电离辐射对人体血液指标的影响  

Effect of medical ionizing radiation on human blood parameters

作　　者：张晔[1] ZHANG Ye(Department of Medical Engineering,Wuxi Municipal People’s Hospital,Wuxi 214200 China)

机构地区：[1]江苏省无锡市人民医院医学工程处,江苏无锡214200

出　　处：《中国辐射卫生》2024年第6期706-709,共4页Chinese Journal of Radiological Health

摘　　要：目的 评价医用电离辐射对人体血细胞和血生化等血液指标的影响,从而为制定辐射防护措施提供参考依据。方法 回顾性收集2007年10月—2024年3月在无锡市人民医院从事X射线和CT扫描等放射诊断、介入治疗、放射治疗等暴露于电离辐射≥10年的工作人员体检资料,以同期在无锡市人民医院从事非暴露电离辐射工作的体检人员300例作为对照,对电离辐射暴露者和未暴露者血细胞、血生化检测结果进行比较分析。结果 电离辐射暴露组和非暴露对照组性别构成(χ^(2)=0.317,P>0.05)、平均年龄差异(t=0.519,P>0.05)均无统计意义。电离辐射暴露组和非暴露对照组白细胞计数(t=11.273,P<0.01)、淋巴细胞计数(t=6.102,P<0.01)、血红蛋白含量(t=67.237,P<0.01)、谷丙转氨酶(t=6.234,P<0.01)、谷草转氨酶(t=4.231,P<0.01)、谷氨酰基转移酶(t=8.010,P<0.01)、总胆红素含量(t=5.212,P<0.01)及谷丙转氨酶(χ^(2)=4.481,P<0.01)、谷氨酰基转移酶(χ^(2)=10.552,P<0.01)、总胆红素异常比例差异(χ^(2)=35.661,P<0.01)均有统计学意义。结论 长期低剂量医用电离辐射暴露可影响人体血细胞和血生化指标。Objective To examine the impact of medical ionizing radiation on human blood cell and biochemical parameters,so as to provide insights into formulation of radiation protective interventions.Methods The health examination data of healthcare workers on radiative diagnosis(X-rays and CT scans),interventional therapy and radiation therapy in Wuxi Municipal People’s Hospital from October 2007 to March 2024 were retrospectively collected,and 300 healthcare workers in the same hospital during the study period without exposure to ionizing radiation served as controls.The blood cell and biochemical parameters were measured and compared between healthcare workers with and without radiation exposure.Results There were no significant differences between healthcare workers with and without radiation exposure in terms of gender distribution(χ^(2)=0.317,P>0.05)and mean age(t=0.519,P>0.05).There were significant differences between healthcare workers with and without radiation exposure in terms of white blood cell counts(t=11.273,P<0.01),lymphocyte counts(t=6.102,P<0.01),hemoglobin level(t=67.237,P<0.01),alanine transaminase(t=6.234,P<0.01),aspartate transaminase(t=4.231,P<0.01),gamma-glutamyl transferase(t=8.010,P<0.01),total bilirubin(t=5.212,P<0.01),and proportions of abnormal alanine transaminase(χ^(2)=4.481,P<0.01),gamma-glutamyl transferase(χ^(2)=10.552,P<0.01)and total bilirubin levels(χ^(2)=35.661,P<0.01).Conclusion Long-term low-dose ionizing radiation may affect human blood cell and biochemical parameters.

关 键 词：电离辐射 血液指标 辐射暴露 血细胞 肝功能 

分 类 号：R144[医药卫生—公共卫生与预防医学]