低剂量辐射生物标志物的研究新进展  

Progress of research on the development of low-dose radiation biomarkers

作　　者：孙鑫 王亚林 刘青杰[1] 李爽[1] SUN Xin;WANG Yalin;LIU Qingjie;LI Shuang(China CDC Key Laboratory of Radiological Protection and Nuclear Emergency,National Institute for Radiological Protection,Chinese Center for Disease Control and Prevention,Beijing 100088 China)

机构地区：[1]中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室,北京100088

出　　处：《中国辐射卫生》2024年第6期728-734,共7页Chinese Journal of Radiological Health

基　　金：国家自然科学基金项目(82173464)。

摘　　要：随着诊断成像、介入医学、放疗及核医学等技术的广泛应用,越来越多的人暴露于低剂量电离辐射中。目前低剂量辐射生物效应尚不明确,因此需要寻找灵敏和特异的生物标志物对低剂量辐射进行风险评估和健康监测。本文从细胞遗传学、DNA损伤、转录组、蛋白质组和代谢组学5个角度对低剂量电离辐射相关生物标志物的最新研究进展进行综述,以期为低剂量辐射生物效应研究提供理论依据。With the widespread adoption of technologies such as diagnostic imaging,interventional medicine,radiotherapy,and nuclear medicine,a growing number of people are exposed to low-dose ionizing radiation.Currently,the biological effects of low-dose radiation remain unclear,necessitating the identification of sensitive and specific biomarkers for risk assessment and health monitoring of such exposure.In this paper,we review the latest research progress in low-dose ionizing radiation biomarkers from the five perspectives of cytogenetics,DNA damage,transcriptome,proteome,and metabolomics.This review aims to provide a theoretical basis for the study of the biological effects of low-dose radiation.

关 键 词：低剂量辐射 生物标志物 生物剂量估算 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]