SAMP8小鼠在抗衰老实验中的应用探析  

Application of SAMP8 Mice in Anti-Aging Experiment

作　　者：吴国庆 汪子栋 焦智博 姜婧[2] 田君健 高效铭 唐银杉[3] 王忠义 孟泽宇 李志刚[1] WU Guoqing;WANG Zidong;JIAO Zhibo;JIANG Jing;TIAN Junjian;GAO Xiaoming;TANG Yinshan;WANG Zhongyi;MENG Zeyu;LI Zhigang(College of Acupuncture and Massage,Beijing University of Chinese Medicine,Beijing 100029,China;School of Nursing,Beijing University of Chinese Medicine,Bejing 100029,China;the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,China;Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Provincial Hospital of Chinese Medicine,Nanjing 210004,China;Nanjing University of Chinese Medicine,Nanjing 210023,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]北京中医药大学针灸推拿学院,北京100029 [2]北京中医药大学护理学院,北京1100029 [3]浙江大学医学院附属第二医院,杭州311100 [4]南京中医药大学附属江苏省中医院,南京210004 [5]南京中医药大学,南京210023 [6]黑龙江中医药大学,哈尔滨150040

出　　处：《世界科学技术-中医药现代化》2024年第12期3040-3052,共13页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金面上项目(82274654):中性粒细胞黏附与内皮修复途径探讨“通督启神”针法干预AD的血脑屏障保护机制研究,负责人:李志刚;国家自然科学基金面上项目(82174515):从“肠道菌群-神经炎症”探讨“通腑升清”针法保护AD神经元的作用机制,负责人:姜婧;北京中医药大学2022年度揭榜挂帅项目(2022-JYB-JBZR-024):穴位敏化的物质基础与成像研究,负责人:李志刚。

摘　　要：快速老化小鼠是日本学者T.Takeda教授实验室在对美国Jackson实验室捐赠的AKR/J品系小鼠的兄妹近交系繁殖产生的子代中筛选出了具有遗传倾向的衰老品系(The senescence accelerate mouse prone,SAMP),且SAMP8小鼠表现出多种衰老特征,如记忆和学习障碍、行为异常、皮肤粗糙老化毛发脱落、眼部病变(视力障碍、白内障、眼周病变)、听力障碍、体质量降低、肌肉力量下降、生殖系统衰老、肝脏和脂肪代谢障碍等病理改变,并广泛应用于相关疾病或病理的实验研究当中,为疾病的研究做出了相当的贡献,但其在应用中也存在诸多问题,如月龄的选择、干预方法的使用、病理变化与研究内容的恰当性,以及不同理论背景下的模型认识等,都极具研究价值,故而本文基于现有文献对上述问题进行系统分析,以求为SAMP8小鼠在不同领域、不同机制的应用提供相关依据。The senescence accelerate mouse prone strain was identified by Professor T.Takeda's laboratory in Japan from the offspring produced by the brother-sister inbred line of AKR/J mice donated by Jackson Laboratory in the United States SAMP,and SAMP8 mice showed a variety of aging characteristics,such as:Pathological changes such as memory and learning disorders,behavioral abnormalities,skin roughness,aging,hair loss,eye lesions(visual impairment,cataract,periocular lesions),hearing impairment,weight loss,muscle strength loss,reproductive system aging,liver and fat metabolism disorders,etc.,are widely used in experimental studies of related diseases or pathology,and have made considerable contributions to the research of diseases.However,there are also many problems in its application,such as the selection of month age,the use of intervention methods,the suitability of pathological changes and research content,and the understanding of models under different theoretical backgrounds,which are of great research value.Therefore,this paper systematically analyzes the above problems based on existing literature,in order to provide relevant basis for the application of SAMP8 mice in different fields and different mechanisms.

关 键 词：快速老化小鼠 病理变化 动物实验 模型应用 

分 类 号：Q95-33[生物学—动物学]