系统性红斑狼疮患者皮肤黏膜损害特点及特异性相关抗体表达情况  

Characteristics of Cutaneous and Mucosal Lesions and Expression of Specificrelated Antibodies in Patients with Systemic Lupus Erythematosus

作　　者：韩燕 王德琴 居保华 杨静雯 HAN Yan;WANG Deqin;JU Baohua;YANG Jingwen(Department of Medical Records,Hai'an People's Hospital,Hai'an,Jiangsu 226600,China;Department of Nephrology,Hai'an People's Hospital,Hai'an,Jiangsu 226600,China)

机构地区：[1]江苏省海安市人民医院病案室,江苏海安226600 [2]江苏省海安市人民医院肾脏内科,江苏海安226600

出　　处：《转化医学杂志》2024年第10期1723-1727,共5页Translational Medicine Journal

基　　金：江苏卫生健康职业学院“医教协同、中西并举”专项项目(202420)。

摘　　要：目的探讨系统性红斑狼疮(SLE)患者皮肤黏膜损害特点及其特异性相关抗体表达情况。方法回顾性选取2019年9月至2024年2月江苏省海安市人民医院411例SLE患者,其中230例患者伴有皮肤黏膜损害为皮损组,181例患者无皮肤黏膜损害为无皮损组,统计皮损组患者皮肤黏膜损害类型,以及2组其他器官受累情况,抗Sm抗体、抗双链DNA(dsDNA)抗体、抗核小体(Nuc)抗体、抗核糖体P蛋白(Rib-P)肽抗原抗体阳性率和水平。结果411例SLE患者中有皮肤黏膜损害230例(55.96%),其中蝶形红斑137例(59.57%)、光敏感95例(41.30%)、指/趾红斑75例(32.61%)、脱发67例(29.13%)、淤点淤斑50例(21.74%)。皮损组肌痛/皮肌炎、关节痛、肾脏、神经系统受累发生率高于无皮损组(P<0.05)。皮损组抗Sm抗体、抗dsDNA抗体阳性率和水平高于无皮损组(P<0.05)。结论SLE患者大部分以蝶形红斑等为特异性皮肤黏膜损害,但非特异性皮肤黏膜损害类型仍占比较大,同时皮肤黏膜损害者抗Sm抗体、抗dsDNA抗体阳性率和水平较高,与其他器官受累具有相关性。Objective To explore the characteristics of skin lesions and the expression of specific-related antibodies in patients with systemic lupus erythematosus(SLE).Methods A retrospective study was carried out on 411SLE patients in Haian People's Hospital,Jiangsu Province from September 2019 to February 2024.Among them,230patients with cutaneous and mucosal lesions were included in the skin lesion group,and 181 patients without cutaneous and mucosal lesions were included in the non-skin lesion group.The types of cutaneous and mucosal lesions in the skin lesion group were counted,as well as the involvement of other organs,and the positive rates and levels of anti-Sm antibody,anti-dsDNA antibody,anti-Nuc antibody and anti-Rib-P antibody in the two groups.Results Among the 411SLE patients,230 cases(55.96%)had cutaneous and mucosal lesions,including 137 cases(59.57%)of butterfly rash,95cases(41.30%)of photosensitivity,75 cases(32.61%)of finger/toe erythema,67 cases(29.13%)of alopecia,and 50 cases(21.74%)of petechiae and ecchymosis.The incidence of myalgia/dermatomyositis,arthralgia,kidney and nervous system involvement in the skin lesion group was higher than that in the non-skin lesion group(P<0.05).The positive rates and levels of anti-Sm antibody and anti-dsDNA antibody in the skin lesion group were higher than those in the non-skin lesion group(P<0.05).Conclusion Most SLE patients have specific cutaneous and mucosal lesions such as butterfly rash,but non-specific cutaneous and mucosal lesion types still account for a large proportion.Meanwhile,the positive rates and levels of anti-Sm antibody and anti-dsDNA antibody in patients with cutaneous and mucosal lesions are higher and correlated with the involvement of other organs.

关 键 词：红斑狼疮 系统性 皮肤黏膜损害 特异性抗体 预后 

分 类 号：R593.241[医药卫生—内科学]