细胞焦亡在运动系统疾病中的作用及相关分子机制  

Role and molecular mechanism of pyroptosis in motor system diseases

作　　者：耿珑玉 盛黎 白硕 高蓓瑶 葛瑞东[3] 江山 Geng Longyu;Sheng Li;Bai Shuo;Gao Beiyao;Ge Ruidong;Jiang Shan(School of Sports Medicine and Rehabilitation,Beijing Sport University,Beijing 100091,China;Department of Rehabilitation Medicine,Beijing Chaoyang District Taiyanggong Community Health Service Center,Beijing 100028,China;Department of Rehabilitation Medicine,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京体育大学运动医学与康复学院,北京市100091 [2]北京市朝阳区太阳宫社区卫生服务中心康复医学科,北京市100028 [3]中日友好医院康复医学科,北京市100029

出　　处：《中国组织工程研究》2025年第26期5695-5703,共9页Chinese Journal of Tissue Engineering Research

基　　金：中央高校基本科研业务费专项资金资助课题(校2020064),项目负责人:葛瑞东;中央高校基本科研业务费专项资金资助课题(2024043),项目负责人:盛黎。

摘　　要：背景:大量研究发现细胞焦亡与运动系统疾病的发生发展密切相关,但细胞焦亡在运动系统疾病中的研究综述较少。目的:综述目前的临床与临床前研究,对细胞焦亡在运动系统疾病中的作用及相关分子机制进行总结,为未来靶向细胞焦亡治疗运动系统疾病提供参考。方法:通过计算机检索PubMed数据库、中国知网的相关文献,检索时限为2000年1月至2024年1月。英文检索词为“pyroptosis,tendons,ligaments,cartilage,muscles,bones”;中文检索词为“焦亡,肌腱,韧带,软骨,骨骼肌,骨骼”。采用主题词和自由词结合的方式进行检索。初步检索422篇文献,其中英文文献334篇,中文文献88篇。排除重复文献、不相关文献后通过全篇阅读进一步排除不具有纳入价值的文献,最终纳入78篇文献进行综述。结果与结论:①细胞焦亡的不同通路及后续引发的炎症反应能够影响运动系统疾病进展和损伤的修复进程;②过度的细胞焦亡不仅可以导致组织细胞的大量死亡,还可以通过细胞裂解后释放的炎症因子等物质加重组织炎症反应、降解细胞外基质,而损伤相关分子模式又可以作为上游信号进一步加重细胞焦亡;③目前针对细胞焦亡防治运动系统疾病的方法主要包括NOD样受体热蛋白结构域相关蛋白3抑制剂、中草药提取物、外泌体治疗、间充质干细胞治疗、运动疗法等;④综述表明,靶向干预细胞焦亡过程中的某些关键因子,或许可以作为一种治疗和预防运动系统疾病的新方向。BACKGROUND:A large number of studies have found that pyroptosis is closely related to the occurrence and development of motor system diseases,but there are few studies and reviews on pyroptosis in motor system diseases.OBJECTIVE:To review the current clinical and preclinical studies,summarize the role of pyroptosis in motor system diseases and related molecular mechanisms,and provide reference for the pyroptosis-targeted treatment for motor system diseases in the future.METHODS:The relevant literatures in PubMed and CNKI database were searched by computer from January 2000 to January 2024.The English search terms were“pyroptosis,tendons,ligaments,cartilage,muscles,bones”and the Chinese search terms were“pyroptosis,tendon,ligament,cartilage,skeletal muscle,bone”in Chinese.A combination of subject terms and free search terms was used.There were a total of 422 documents,including 334 in English and 88 in Chinese.After excluding duplicate literature and irrelevant literature,the literature without inclusion value was further excluded by reading the whole paper,and finally 78 documents were included for review and analysis.RESULTS AND CONCLUSION:Different pathways of pyroptosis and subsequent inflammatory responses can affect the progression of motor system diseases and the repair process of injuries.Excessive pyroptosis can not only cause a large number of tissue cells to die,but also aggravate tissue inflammation and degrade the extracellular matrix through substances such as inflammatory factors released after cell lysis,and damaging related molecular patterns can act as upstream signals to further aggravate pyroptosis.Current methods for preventing and treating motor system diseases mainly include NOD-like receptor thermal protein domain-associated protein 3 inhibitors,Chinese herbal extracts,exosome therapy,mesenchymal stem cell therapy,and exercise therapy.The review suggests that targeted intervention of some key factors in the process of pyroptosis may be a new direction for the treatment and preventio

关 键 词：细胞焦亡 骨骼 骨骼肌 肌腱 软骨 炎症因子 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R68