高危型人乳头状瘤病毒感染患者的阴道微生物特征分析  

Analysis of vaginal microbial characteristics in patients with high-risk human papilloma virus infection

作　　者：张琴 路宗林 ZHANG Qin;LU Zonglin(Department of Laboratory,Youyi Hospital of Yili Kazakh Autonomous Prefecture,Xinjiang Uygur Autonomous Region,Yili 835000,China;Department of Obstetrics,Youyi Hospital of Yili Kazakh Autonomous Prefecture,Xinjiang Uygur Autonomous Region,Yili 835000,China)

机构地区：[1]新疆维吾尔自治区伊犁哈萨克自治州友谊医院检验科,新疆伊犁835000 [2]新疆维吾尔自治区伊犁哈萨克自治州友谊医院产科,新疆伊犁835000

出　　处：《妇儿健康导刊》2025年第2期43-46,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的分析高危型人乳头状瘤病毒(HPV)感染患者的阴道微生物特征。方法回顾性分析2020年2月至2023年2月伊犁哈萨克自治州友谊医院收治的100例HPV感染患者的临床资料,根据HPV类型分为高危组、低危组,各50例。分析两组微生物菌落类型、菌门分布情况、阴道感染情况、阴道感染微生物分布情况。结果高危组微生物菌落类型Ⅰ、Ⅱ、Ⅲ、Ⅴ型优势菌比例均低于低危组,Ⅳ型比例高于低危组(P<0.05)。高危组厚壁菌门比例高于低危组,变形菌门、放线菌门、拟杆菌门、无壁菌门、梭菌门比例均低于低危组(P<0.05)。高危组阴道感染率[80.00%(40/50)]高于低危组[50.00%(25/50)](P<0.05)。两组阴道支原体、细菌、真菌、沙眼衣原体、滴虫感染率比较无差异(P>0.05)。结论高危型HPV感染患者阴道优势菌较少,阴道感染率较高,主要为细菌感染、支原体感染。Objective To analyze the characteristics of vaginal microbiota in patients with high-risk human papilloma virus(HPV)infection.Methods The clinical data of 100 patients with HPV infection admitted to the Youyi Hospital of Yili Kazakh Autonomous Prefecture from February 2020 to February 2023 were retrospectively analyzed.According to the type of HPV,they were divided into high-risk group and low-risk group,with 50 cases in each group.The types of microbial colonies,the distribution of bacterial phyla,vaginal infection,and the distribution of vaginal infection microorganisms were analyzed.Results The proportion of dominant bacteria of typesⅠ,Ⅱ,Ⅲ,andⅤin high-risk group was lower than that in low-risk group,and the proportion of typeⅣwas higher than that in lowrisk group(P<0.05).The proportion of Firmicute in high-risk group was higher than that in low-risk group,and the proportion of Proteobacteria,Actinobacteria,Bacteroidetes division,Phylum Tenericutes and Fusobacteria was lower than that in low-risk group(P<0.05).The vaginal infection rate of high-risk group(80.00%[40/50])was higher than that of low-risk group(50.00%[25/50])(P<0.05).There were no significant differences in the infection rates of Mycoplasma,Bacteria,Fungi,Chlamydia trachomatis,and trichomonas in the vagina between the two groups(P>0.05).Conclusion Patients with high-risk HPV infection have few dominant vaginal bacteria,and the vaginal infection rate is higher,mainly Bacterial infection and Mycoplasma infection.

关 键 词：高危型人乳头状瘤病毒感染 阴道微生物特征 微生物菌落类型 阴道感染 

分 类 号：R446[医药卫生—诊断学]