腹腔镜输卵管妊娠物清除术联合甲氨蝶呤治疗输卵管妊娠的临床效果  

Clinical effect of laparoscopic tubal pregnancy removal combined with Methotrexate in the treatment of tubal pregnancy

作　　者：张广银 ZHANG Guangyin(Department of Gynecology,Renhuai Traditional Chinese Medicine Hospital,Guizhou Province,Renhuai 564500,China)

机构地区：[1]贵州省仁怀市中医院妇科,贵州仁怀564500

出　　处：《妇儿健康导刊》2025年第2期76-79,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨腹腔镜输卵管妊娠物清除术联合甲氨蝶呤治疗输卵管妊娠的临床效果。方法选取2022年1月至2023年9月仁怀市中医院收治的96例输卵管妊娠患者,使用随机数字表法将其分为两组,每组各48例。对照组行药物保守治疗,观察组给予腹腔镜下输卵管妊娠物清除术联合甲氨蝶呤,比较两组临床疗效、血清学指标、输卵管畅通率及宫内受孕率。结果观察组治愈率为100.00%,输卵管畅通率为91.67%,宫内受孕率为54.17%,高于对照组的81.25%、75.00%、29.17%,差异有统计学意义(P<0.05);治疗前,两组血清学指标比较,差异无统计学意义(P>0.05);治疗1周后,观察组血管内皮生长因子水平为(198.71±10.52)mmol/L,抑制素A水平为(102.85±8.64)ng/L、孕酮水平为(12.21±2.42)nmol/L,低于对照组的(218.66±13.35)mmol/L、(119.45±9.43)ng/L、(16.60±3.75)nmol/L,差异有统计学意义(P<0.05)。结论腹腔镜输卵管妊娠物清除术联合甲氨蝶呤治疗输卵管妊娠的临床效果较好,可以使输卵管畅通,改善血清学指标,提高宫内受孕率。Objective To explore the clinical effect of laparoscopic tubal pregnancy removal combined with Methotrexate in the treatment of tubal pregnancy.Methods A total of 96 patients with tubal pregnancy admitted to Renhuai Traditional Chinese Medicine Hospital from January 2022 to September 2023 were selected and divided into two groups using random number table method,with 48 cases in each group.The control group received conservative drug treatment,while the observation group was given laparoscopic tubal pregnancy removal combined with Methotrexate.The clinical efficacy,serological indexes,fallopian tube patency rate and intrauterine pregnancy rate were compared between the two groups.Results The cure rate of the observation group was 100.00%,the fallopian tube patency rate was 91.67%,and the intrauterine pregnancy rate was 54.17%,which were higher than those in the control group(81.25%,75.00%,and 29.17%),with statistical significance(P<0.05).There were no statistically significant difference in serum indexes between the two groups before treatment(P>0.05).After one week of treatment,the levels of vascular endothelial growth factor,inhibin A and progesterone in the observation group were(198.71±10.52)mmol/L,(102.85±8.64)ng/L and(12.21±2.42)nmol/L,respectively,which were lower than those of control group([218.66±13.35]mmol/L,[119.45±9.43]ng/L,[16.60±3.75]nmol/L),the differences were statistically significant(P<0.05).Conclusion Laparoscopic tubal pregnancy removal combined with Methotrexate in the treatment of tubal pregnancy has a good clinical effect,which can make the fallopian tube open,improve serological indicators,and increase the intrauterine pregnancy rate.

关 键 词：输卵管妊娠 腹腔镜下输卵管妊娠物清除术 甲氨蝶呤 输卵管畅通率 宫内受孕率 

分 类 号：R714.22[医药卫生—妇产科学]