针灸抑制铁死亡治疗膝骨关节炎研究进展  

Research Progress on the Inhibition of Ferroptosis by Acupuncture and Moxibustion in the Treatment of Knee Osteoarthritis

作　　者：董逸波 唐锐 杨涵翔 樊效鸿[1] 余洋[1] DONG Yibo;TANG Rui;YANG Hanxiang;FAN Xiaohong;YU Yang(Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610000,Sichuan,China)

机构地区：[1]成都中医药大学附属医院,四川成都610000

出　　处：《辽宁中医药大学学报》2025年第2期79-83,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2019YFC1712505);四川省中医药管理局科学技术研究专项课题(2023ZD025)。

摘　　要：膝骨关节炎(knee osteoarthritis,KOA)是一种常见的退行性骨关节疾病,其主要特征包括软骨退化、软骨下骨硬化和滑膜炎症。近年来,铁死亡作为一种新发现的非凋亡性细胞死亡方式,在加速KOA的进程中被认为起着至关重要的作用。铁死亡通过促进脂质过氧化、炎症反应和氧化应激的相互作用,导致软骨退化和滑膜炎症,其在KOA中的机制探究为疾病治疗提供了新的视角。针灸,这一传统治疗方法,已被研究证实具有通过调节Nrf2信号通路、铁代谢和脂质过氧化来抑制铁死亡的潜在能力。这种调节作用有助于激活抗氧化防御基因,降低氧化应激,减轻炎症反应,并在分子层面上保护软骨细胞。此外,针灸还可能通过影响神经传导路径和中枢机制,有效减轻KOA患者的疼痛感。该文综述了铁死亡的基本概念、触发机制,并探讨了针灸在抑制铁死亡、保护软骨细胞方面的潜在作用。通过深入分析,文章为理解KOA的发病机制提供了新的维度,并为针灸治疗KOA提供了科学依据和新的治疗策略,展现了针灸在现代医学中的新价值和应用前景。Knee osteoarthritis(KOA)is a prevalent degenerative joint disorder characterized by the triad of articular cartilage degeneration,subchondral bone sclerosis,and synovial inflammation.In recent years,ferroptosis is a newly identified form of non-apoptotic cell death,has emerged as a critical player in the acceleration of KOA progression.This process is driven by the interplay of lipid peroxidation,inflammatory responses,and oxidative stress,which together contribute to cartilage degeneration and synovial inflammation.The elucidation of the role of ferroptosis in KOA offers novel insights into disease pathogenesis and therapeutic intervention.Acupuncture,an ancient therapeutic modality,has been demonstrated through research to possess the potential to inhibit ferroptosis by modulating the Nrf2 signaling pathway,iron metabolism,and lipid peroxidation.This regulatory effect facilitates the activation of antioxidant defense genes,reduction of oxidative stress,mitigation of inflammatory responses,and molecular-level protection of chondrocytes.Moreover,acupuncture may alleviate pain in KOA patients by influencing neural conduction pathways and central mechanisms.This review synthesizes the fundamental concepts and triggering mechanisms of ferroptosis and explores the potential role of acupuncture in inhibiting ferroptosis and safeguarding chondrocytes.Through in-depth analysis,this article provides a new perspective on understanding the pathogenesis of KOA and presents scientific evidence and novel therapeutic strategies for the treatment of KOA with acupuncture,highlighting its emerging value and prospects in modern medicine.

关 键 词：针灸 铁死亡 膝骨关节炎 中医药 

分 类 号：R245[医药卫生—针灸推拿学]