中药黄连治疗2型糖尿病药理机制研究进展  

Research on the Pharmacological Mechanism of Traditional Chinese Medicine Huanglian(Coptidis Rhizoma)in the Treatment of Type 2 Diabetes Mellitus

作　　者：陈可 张效科[1] CHEN Ke;ZHANG Xiaoke(Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046

出　　处：《辽宁中医药大学学报》2025年第2期94-98,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81774304);西安市卫生健康委员会中医学术流派传承工作室建设项目。

摘　　要：2型糖尿病(T2DM)是一组由遗传因素和环境因素综合作用引起的多基因遗传性疾病,主要以胰岛素抵抗和β细胞胰岛素分泌缺陷为两大病理机制。黄连作为治疗2型糖尿病的常用药物,具有清热燥湿之功效,符合2型糖尿病内热为主的基本病机。通过查阅相关文献,发现黄连药理作用十分广泛,该药通过多靶点、多效应、多途径治疗2型糖尿病,可有效缓解病情的发展及并发症的发生。黄连中含有多种有效成分,主要包括小檗碱(黄连素)、黄连碱、木脂素类、苯丙酸、黄酮类、挥发油及其他活性类成分等,发挥抗氧化应激、调节炎症反应、调控自噬、增强胰岛功能及调节肠道菌群等作用,且在2型糖尿病治疗上疗效显著。该文阐释了黄连中有效成分治疗2型糖尿病的药理机制,以期为黄连治疗2型糖尿病的未来研究方向提供参考。Type 2 diabetes mellitus(T2DM)is a group of genetic inherited diseases caused by a combination of genetic and environmental factors,mainly insulin resistance andβcell insulin secretion deficiency as two major pathological mechanisms.Huanglian(Coptidis Rhizoma),as a commonly used drug in the treatment of type 2 diabetes,has the effect of clearing heat and drying dampness,which is in line with the basic pathogenesis of type 2 diabetes.Through the review of relevant literature,it was found that Huanglian(Coptidis Rhizoma)has a wide range of pharmacological effects,which treated type 2 diabetes through multi-target,multi-effect and multi-pathway,and can effectively alleviate the development of the disease and the occurrence of complications.Huanglian(Coptidis Rhizoma)contains a variety of active ingredients,mainly including berberine,coptis,lignans,phenylpropionic acid,flavonoids,volatile oils and other active classes,which play the role of anti-oxidative stress,regulation of inflammation,regulation of autophagy,enhancement of islet function and regulation of intestinal flora,and has significant therapeutic effect in the treatment of type 2 diabetes.In this paper,the pharmacological mechanism of the active ingredients of Huanglian(Coptidis Rhizoma)in the treatment of type 2 diabetes was summarized in order to provide reference for the future research direction of Huanglian(Coptidis Rhizoma)in the treatment of type 2 diabetes.

关 键 词：黄连 2型糖尿病 药理机制 研究进展 

分 类 号：R255.4[医药卫生—中医内科学]