桂枝茯苓丸药理研究进展  

Progress of Pharmacological Studies on Guizhi Fuling Pills(桂枝茯苓丸)

作　　者：张天婵[1] 刘颖[2] 张梦颖 ZHANG Tianchan;LIU Ying;ZHANG Mengying(The Second Hospital Affiliated to Heilongjiang University of Chinese Medicine,Harbin 150001,Heilongjiang,China;Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《辽宁中医药大学学报》2025年第2期190-195,共6页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81704113)。

摘　　要：出自《金匮要略》的经典名方桂枝茯苓丸有活血化瘀、缓消癥块之效,由等量桂枝、茯苓、芍药、牡丹皮和桃仁组成。现代药理研究发现,桂枝具有镇痛、抗血小板凝集、抗肿瘤和抗炎等作用;茯苓则有调控血糖血脂、抗氧化、免疫调节、抗炎和抗肿瘤等效果;芍药具备抗抑郁、抗氧化、抗炎、抗癌、抗动脉粥样硬化和降血糖等作用;牡丹皮可抗癌、抗炎、抗氧化、降血糖和血压、调节血脂代谢以及抗血栓;桃仁亦具备抗凝血、抗炎、抗肿瘤以及抗纤维化能力。桂枝茯苓丸药理作用丰富,随着众多学者对其药理作用研究的不断深入,其临床应用越来越广泛。该方涉及妇产科疾病如炎性增生、月经病、产育病和恶性肿瘤、子宫内膜异位症、不孕症等妇科杂病;内科疾病如呼吸、精神神经、泌尿生殖以及内分泌与代谢等系统疾病;外科疾病如乳腺增生、下肢静脉曲张等;皮肤科疾病包括慢性光化性皮炎、女性黑眼圈等。该文通过查阅近五年桂枝茯苓丸相关文献资料,对药理研究内容进行整理、归纳并总结,分别从方药组成、成分与作用,方药药理作用以及临床应用现状等角度,对桂枝茯苓丸的药理研究进行综述,以期为后续药物研究、药物开发以及疾病治疗提供参考。Guizhi Fuling Pills(桂枝茯苓丸),a classic formula from the Essentials of the Golden Chamber,is effective in activating blood circulation,removing blood stasis and easing the elimination of lumps and masses,and consists of equal parts of Guizhi(Cinnamomi Ramulus),Fuling(Poria),Shaoyao(Paeoniae Radix Rubra),Mudanpi(Moutan Cortex)and Taoren(Persicae Semen).Modern pharmacological studies have found that Guizhi(Cinnamomi Ramulus)has analgesic,anti-platelet aggregation,anti-tumour and anti-inflammatory effects;Fuling(Poria)has the effects of regulating blood glucose and blood lipids,antioxidant,immune modulation,anti-inflammatory and anti-tumour effects;Shaoyao(Paeoniae Radix Rubra)is antidepressant,antioxidant,anti-inflammatory,anticancer,anti-atherogenic,anti-glycaemia and anti-hyperglycaemia effects;Mudanpi(Moutan Cortex)has the effects of anti-cancer,anti-inflammatory,antioxidant,lowering of blood glucose and blood pressure,regulation of lipid metabolism,and antithrombotic;Taoren(Persicae Semen)also possesses anti-coagulant,anti-inflammatory,anti-tumour and anti-fibrotic properties.Guizhi Fuling Pills is rich in pharmacological effects,and its clinical application is becoming more and more extensive as many scholars continue to deepen the research on its pharmacological effects.The formula involves obstetrics and gynaecology diseases such as inflammatory hyperplasia,menstrual disease,obstetrics and malignant tumours,endometriosis,infertility and other gynaecological diseases;internal medicine diseases such as respiratory,psycho-neurological,genitourinary and endocrine and metabolic system diseases;surgical diseases such as mammary gland hyperplasia,varicose veins of the lower limbs,etc;and dermatology diseases such as chronic photochemical dermatitis and dark circles of the eyes in women.In this paper,by reviewing the literature related to Guizhi Fuling Pills in the past five years,we have collated,summarized and summarized the pharmacological research contents,and reviewed the pharmacological research of Guiz

关 键 词：桂枝茯苓丸 成分 药理作用 研究进展 

分 类 号：R285[医药卫生—中药学]