急性心肌梗死患者血清桥粒芯糖蛋白2、半乳糖凝集素-3 mRNA表达水平与院内心源性猝死的相关性分析  

Correlation analysis between serum desmoglein 2 and galectin-3 mRNA expression levels and in-hospital sudden cardiac death in patients with acute myocardial infarction

作　　者：赵小芳 王泰然[1] 李娜[1] 安莎莎 谭珊 李燕平 Zhao Xiaofang;Wang Tairan;Li Na;An Shasha;Tan Shan;Li Yanping(Department of General Medicine,Handan Central Hospital,Handan 056000,China)

机构地区：[1]河北省邯郸市中心医院全科医学科,056000

出　　处：《心脑血管病防治》2024年第12期38-42,共5页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：河北省医学科学研究课题计划项目(20200197)。

摘　　要：目的探讨急性心肌梗死(AMI)患者血清桥粒芯糖蛋白2(DSG2)、半乳糖凝集素-3(Gal-3)m RNA表达水平与院内心源性猝死(SCD)的相关性。方法选取2019年1月至2022年8月邯郸市中心医院发生院内SCD的AMI患者89例作为SCD组,同期住院治疗的92例单纯AMI患者为单纯AMI组。比较两组患者一般临床资料;采用实时荧光定量PCR法检测血清DSG2mRNA、Gal-3 mRNA表达水平;Pearson法分析AMI发生院内SCD患者血清DSG2 mRNA、Gal-3 mRNA表达水平与左心室射血分数(LVEF)、心肌肌钙蛋白T(cTnT)的相关性以及血清DSG2mRNA与Gal-3 mRNA表达水平的相关性;Logistic回归分析AMI患者发生院内SCD的影响因素;受试者工作特征曲线评估血清DSG2 mRNA、Gal-3 mRNA表达水平对AMI患者发生院内SCD的预测价值。结果与单纯AMI组相比,SCD组患者LVEF、血清DSG2 mRNA表达水平降低,cTnT、血清Gal-3 mRNA表达水平升高(t=6.163、8.288、16.484、10.009,P<0.05);发生院内SCD的AMI患者血清DSG2 mRNA表达水平与LVEF呈正相关,与cTnT、Gal-3 mRNA水平呈负相关(r=0.476、-0.379、-0.598,P<0.05);Gal-3 mRNA表达水平与LVEF呈负相关,与cTnT呈正相关(r=-0.362、0.428,P<0.05);血清DSG2 mRNA和Gal-3 mRNA预测AMI患者发生院内SCD的AUC分别为0.869、0.854,两者联合预测AMI患者发生SCD的AUC为0.946,高于单独预测(Z=2.453、2.778,P<0.05),敏感度为94.4%,特异度为81.5%。结论AMI发生院内SCD的AMI患者血清DSG2 mRNA呈低表达,Gal-3 mRNA呈高表达,两者可为临床早期防治AMI患者发生院内SCD提供预测。Objective To analyze the correlation between serum desmoglein 2(DSG2)and galectin-3(Gal-3)mRNA expression levels and in-hospital sudden cardiac death(SCD)in patients with acute myocardial infarction(AMI).Methods A total of 89 AMI patients who experienced in-hospital SCD at Handan Central Hospital from January 2019 to August 2022 were selected as the SCD group,and 92 hospitalized patients with pure AMI during the same period were selected as the pure AMI group.General clinical data of the two groups were compared.Serum DSG2 and Gal-3 mRNA expression levels were detected by real-time fluorescent quantitative PCR.Pearson method was used to analyze the correlations of serum DSG2 and Gal-3 mRNA expression levels with left ventricular ejection fraction(LVEF),cardiac troponin T(cTnT),and each other in AMI patients with in-hospital SCD.Logistic regression analysis was applied to analyze factors influencing in-hospital SCD in AMI patients.The predictive value of serum DSG2 and Gal-3 mRNA expression levels for in-hospital SCD in AMI patients was evaluated using receiver operating characteristic(ROC)curve analysis.Results Compared with the pure AMI group,the SCD group had lower LVEF and serum DSG2 mRNA expression levels,and higher cTnT and serum Gal-3 mRNA expression levels(t=6.163,8.288,16.484,10.009;P<0.05).In AMI patients with SCD,serum DSG2 mRNA expression levels were positively correlated with LVEF and negatively correlated with cTnT and Gal-3 mRNA levels(r=0.476,-0.379,-0.598;P<0.05).Gal-3 mRNA expression levels were negatively correlated with LVEF and positively correlated with cTnT(r=-0.362,0.428;P<0.05).The areas under the ROC curve(AUC)for predicting in-hospital SCD using serum DSG2 and Gal-3 mRNA levels were 0.869 and 0.854,respectively.The combined prediction of AUC for SCD in AMI patients was 0.946,with a sensitivity of 94.4%and specificity of 81.5%,which was significantly higher than using either marker alone(Z=2.453,2.778;P<0.05).Conclusion Serum DSG2 mRNA expression is low and Gal-3 mRNA expression is high i

关 键 词：急性心肌梗死 桥粒芯糖蛋白2 半乳糖凝集素-3 心源性猝死 

分 类 号：R54[医药卫生—心血管疾病]