关注环境温度对骨代谢的影响  

Focus on the influence of ambient temperature on bone metabolism

作　　者：雷丽敏 许丰[1] 李付杏子 单素康 郑明慧 唐可欣 林潇[2] 袁凌青[1] LEI Li-min;XU Feng;LI Fu-xing-zi;SHAN Su-kang;ZHENG Ming-hui;TANG Ke-xin;LIN Xiao;YUAN Ling-qing(Department of Metabolism and Endocrinology,The Second Xiangya Hospital,Central South University,Changsha 410011,China;Department of Radiology,The Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院代谢内分泌科,长沙410011 [2]中南大学湘雅二医院放射科,长沙410011

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第6期549-552,共4页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：低温暴露显著增加了骨折风险,且对骨质量有不利影响,可能通过影响能量分配、神经肽Y调控、血浆外泌体等途径导致骨质流失。另一方面,高温环境可能通过增加骨量和改善骨骼微结构来发挥保护作用,且与骨折风险降低相关。此外,温度还能够直接调节软骨细胞的生长与代谢,进而影响骨骼生长。本文从基础研究和流行病学角度分析了环境温度对骨代谢的双重作用,既包括对疾病预防的启示,也提供了基于温度调节的治疗方法的构想。本文为骨质疏松和骨健康管理提供了新的思路,尤其在极端温度频发的现代气候背景下,适当调整温度暴露有望成为骨骼疾病防治的新方法。Exposure to low temperatures significantly increases the risk of fractures and negatively impacts bone quality,possibly through pathways involving energy distribution,neuropeptide Y regulation,and plasma exosome activity,leading to bone loss.Conversely,high-temperature environments may offer protective benefits by safeguarding bone quality and improving bone microstructure,which is associated with a reduced risk of fractures.Additionally,temperature can directly regulate the growth and metabolism of chondrocytes,thereby influencing bone growth.This article analyzes the dual effects of environmental temperature on bone metabolism from both basic research and epidemiological perspectives,providing insights into disease prevention and proposing temperature modulation as a potential treatment approach.The research suggests new strategies for clinical management of osteoporosis and bone health,particularly in the context of extreme temperatures that are increasingly prevalent in modern climates,indicating that appropriate adjustment of temperature exposure may emerge as a novel method for preventing and treating bone diseases.

关 键 词：环境温度 骨质疏松 骨折 骨代谢 

分 类 号：R681[医药卫生—骨科学]