中国中老年人衰弱与可能肌少症共病的潜在危险因素研究  

Influencing factors of comorbidity of frailty and possible sarcopenia among middle-aged and elderly Chinese adults

作　　者：蒋安琪 梁博 魏玥 裴丽君[1] JIANG An-qi;LIANG Bo;WEI Yue;PEI Li-jun(Institute of Population Research/Chinese Center for Population Health and Development,Peking University,Beijing 100871,China)

机构地区：[1]北京大学人口研究所,北京100871

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第6期564-573,共10页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家重点研发计划(2018YFC2000603);国家自然科学基金(41871360)。

摘　　要：目的探讨中国中老年人衰弱与可能肌少症共病的潜在影响因素。方法利用2011—2015年中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS)数据,使用衰弱指数(Frailty index,FI)评价中老年人的衰弱状况,通过测量握力和重复5次起坐时间判断可能肌少症。使用Logistic回归分析中老年人衰弱与可能肌少症共病的可能危险因素。结果衰弱和可能肌少症共病的多因素Logistic回归分析结果显示,年龄<60岁的人群,教育程度为小学及以下(OR=2.42,95%CI:1.24~4.74)、有跌倒史(OR=3.46,95%CI:1.79~6.68)与衰弱和可能肌少症共病风险增加存在关联,饮酒习惯与衰弱和可能肌少症共病风险降低存在关联(OR=0.34,95%CI:0.12~0.95);年龄≥60岁人群中,生活满意度为一般(OR=1.92,95%CI:1.10~3.33)和不满意(OR=3.80,95%CI:2.07~6.97)、有跌倒史(OR=2.11,95%CI:1.43~3.10)、腰高比>0.5(OR=2.12,95%CI:1.26~3.56)和有抑郁情绪(OR=3.07,95%CI:2.00~4.71)均与衰弱和可能肌少症共病风险增加存在关联,有饮酒习惯(OR=0.54,95%CI:0.34~0.87)与衰弱和可能肌少症共病风险降低存在关联。结论年龄为≥60岁、生活满意度较低、有跌倒史、中心性肥胖和有抑郁情绪可能是衰弱与可能肌少症共病的高危人群,针对潜在的高危人群尽早采取干预措施,延缓衰弱和可能肌少症的发生、发展。Objective To analyze the comorbidity influencing factors of frailty and possible sarcopenia among middle-aged and elderly Chinese adults.Methods Frailty index(FI)was applied to evaluate frailty status,grip strength and repetitive sitting-up time was applied to determine possible sarcopenia.Data used in this study was from the China Health and Retirement Longitudinal Study(CHARLS)in 2011—2015.Multiple Logistic regression analysis was conducted to explore the influencing factors of comorbidity of frailty and possible sarcopenia.Results The results of multivariate Logistic regression analysis showed that for those aged<60 years,the rate of comorbidity was higher in education level of primary school and below(OR=2.42,95%CI:1.24-4.74),with history of falls(OR=3.46,95%CI:1.79-6.68).Results also showed that drinking habits(OR=0.34,95%CI:0.12-0.95)were protective for comorbidity.Among those aged≥60 years,the rate of comorbidity was higher in those of average(OR=1.92,95%CI:1.10-3.33)or unsatisfied(OR=3.80,95%CI:2.07-6.97)with life,with history of falls(OR=2.11,95%CI:1.43-3.10),waist-to-height ratio>0.5(OR=2.12,95%CI:1.26-3.56),with depressed mood(OR=3.07,95%CI:2.00-4.71).Drinking habits(OR=0.54,95%CI:0.34-0.87)were protective for comorbidity.Conclusion Among people aged 60 years and older,low life satisfaction,history of falls,central obesity,and depressed mood may be the high risks for comorbidity of frailty and possible sarcopenia.Early interventions for potentially at-risk populations can be taken to slow the progression of the disease.

关 键 词：衰弱 可能肌少症 衰弱与可能肌少症共病 中老年人 

分 类 号：R681[医药卫生—骨科学]