骨质疏松症相关基因研究进展  

Research progress of osteoporosis related genes

作　　者：朱丽娴 王艳华[1] 余鑫 ZHU Li-xian;WANG Yan-hua;YU Xin(The Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,China Three Gorges University,Yichang,Hubei 443002,China;Department of orthopedics,Yichang Yiling People's Hospital,Yichang,Hubei 443100,China)

机构地区：[1]肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学),湖北宜昌443002 [2]宜昌市夷陵人民医院骨科,湖北宜昌443100

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第6期611-622,共12页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：2023年度肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学)开放基金课题(2023KZL03)。

摘　　要：骨质疏松症是一种随年龄增长而出现的骨质退化性疾病,其特点是骨形成能力下降和骨吸收作用增强,常导致骨折发生。近年来,骨质疏松症相关基因研究取得了较大进展,在延缓骨质疏松症疾病进展中,相继发现了降钙素基因相关肽(calcitonin gene-related peptide,CGRP)、微小RNA(microRNA,miRNA)等基因对骨质疏松症的具体调控机制。而在促进骨质疏松症疾病发展进程中,也发现了核因子κB受体活化因子配体(receptor activator of nuclear factor-κB ligand,RANKL)、叉头蛋白F1(forkhead protein F1,Foxf1)、脂肪量和肥胖相关蛋白(fat mass and obesity-associated protein,FTO)等基因对骨质疏松症疾病的调控方式。本文就促进骨质疏松症和抑制骨质疏松症相关基因在骨质疏松症病理进程中的作用机制进行总结,以期为骨质疏松症的临床治疗提供一定的参考。Osteoporosis is a bone degenerative disease with aging,which is characterized by decreased bone formation and increased bone resorption,often accompanied by fracture.In recent years,great progress has been made in the study of osteoporosis-related genes.Calcitonin gene-related peptide(CGRP),microRNA(microRNA)have been found in delaying the progression of osteoporosis.In addition,receptor activator of nuclear factor-κB ligand(RANKL),forkhead protein F1(Foxf1),and fat mass and obesity-associated protein(FTO)have also been found to promote the development of osteoporosis.This article summarizes the mechanism of promoting osteoporosis and inhibiting osteoporosis related genes in the pathological process of osteoporosis,in order to provide some reference for the clinical treatment of osteoporosis.

关 键 词：骨质疏松症 降钙素基因相关肽 核因子ΚB受体活化因子配体 微小RNA 

分 类 号：R681[医药卫生—骨科学]