骨质疏松症的孟德尔随机化研究  

Mendelian randomization study of osteoporosis

作　　者：王炳霖 刘汝银[2] 岳宗进[2] 王新立[2] WANG Bing-lin;LIU Ru-yin;YUE Zong-jin;WANG Xin-li(College of Orthopedics and Traumatology,Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Department of Spine,Second Affiliated Hospital of Southern University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学骨伤学院,郑州450000 [2]河南中医药大学第二附属医院脊柱科,郑州450000

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第6期638-647,共10页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：河南省中医药科学研究专项基金项目(2022ZY1092)。

摘　　要：随着孟德尔随机化(Mendelian randomization,MR)研究方法的出现与发展,对于骨质疏松症(osteoporosis,OP)的MR研究也不断增多,关于OP影响因素的研究得到了更可靠的技术支持,以往研究的真实性得到了进一步验证。通过MR研究,研究者得以更好地探索诸多因素与OP的因果关系。本文概述了关于OP的MR研究最新进展,全面分析生活、疾病、生化等多方面因素与OP之间的潜在联系。With the emergence and development of Mendelian randomization(MR)as a research method,MR studies on osteoporosis(OP)have been increasing,providing more reliable technical support for studying the influencing factors of OP.The authenticity of previous studies has been further validated.Through MR studies,we can better explore the causal relationships related to OP.This review summarizes the latest progress in MR research on OP.The relationship between OP and many factors such as life,disease and biochemistry was analyzed.

关 键 词：危险因素 相关性 骨质疏松症 孟德尔随机化 

分 类 号：R681[医药卫生—骨科学]