分析吸入用布地奈德混悬液联合硫酸特布他林雾化吸入用溶液治疗小儿毛细支气管炎的临床疗效及对血清IL-4、IL-6、IL-8、TNF-α、IFN-γ的影响  

Clinical Curative Effect of Inhaled Budesonide Suspension Combined withTerbutaline Sulfate Aerosol Inhalation Solution and its Influences on SerumIL-4, IL-6, IL-8, TNF-α and IFN-γ in Children with Bronchiolitis

作　　者：张媛昊 Zhang Yuanhao(Department of Pediatrics,Anshun People’s Hospital,Anshun Guizhou 561000)

机构地区：[1]贵州省安顺市人民医院儿科,贵州安顺561000

出　　处：《黑龙江医药》2025年第1期33-37,共5页Heilongjiang Medicine journal

基　　金：安顺市科技计划项目(安市科社﹝2022﹞43号)。

摘　　要：目的:本次研究系统性分析吸入用布地奈德混悬液与硫酸特布他林雾化吸入用溶液联合治疗方案,在小儿毛细支气管炎治疗中的实际效果,实现治疗方案的创新与完善。方法:收集2019年5月—2023年12月间本院儿科收治的60例毛细支气管炎患儿,根据随机数字表法分组,每组各30例。对照组在整个治疗过程中,接受吸入用布地奈德混悬液治疗方案,观察组在对照组用药方案的基础上,追加硫酸特布他林雾化吸入用溶液治疗,对比两组患儿的临床疗效、症状缓解情况、血清因子表达及安全性。结果:观察组治疗后的总有效率为93.33%,比对照组的73.33%高(P<0.05);观察组患儿的喘憋、气促、咳嗽、胸闷、湿啰音及哮鸣音消失时间均比对照组短,同时心率恢复时间及出院时间也比对照组短(P<0.05);观察组治疗后的血清IL-4、IL-6、IL-8、TNF-α表达均比对照组低,而IFN-γ则比对照组高(P<0.05);观察组中的不良反应发生率为10.00%,对照组为16.67%,其比较差异无统计学意义(P>0.05)。结论:吸入用布地奈德混悬液联合硫酸特布他林雾化吸入用溶液治疗小儿毛细支气管炎的临床疗效显著,有助于促进其症状缓解,改善血清因子表达,且安全性较高。Objective:To systematically analyze the practical curative effect of inhaled budesonide suspension combined with terbutaline sulfate aerosol inhalation solution in children with bronchiolitis so as to realize the innovation and improvement of therapeutic regimens.Methods:A total of 60 children with bronchiolitis admitted to Pediatrics Department of the hospital were enrolled between May 2019 and December 2023.According to random number table method,they were divided into control group(inhaled budesonide suspension)and observation group(terbutaline sulfate aerosol inhalation solution on basis of control group),30 cases in each group.Clinical curative effect,symptoms remission,serum factors and safety in the two groups were compared.Results:After treatment,total response rate of observation group was higher than that of control group(93.33%VS 73.33%,P<0.05).The disappearance time of symptoms(dyspnea,shortness of breath,cough,chest tightness,moist rale,wheezing rale)in observation group was shorter than that in control group,recovery time of heart rate and discharge time were also shorter than those in control group(P<0.05).After treatment,levels of serum IL-4,IL-6,IL-8 and TNF-αin observation group was lower than those in control group,while IFN-γwas higher than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between observation group and control group(10.00%VS 16.67%,P>0.05).Conclusion:Clinical curative effect of inhaled budesonide suspension combined with terbutaline sulfate aerosol inhalation solution is significant in children with bronchiolitis,which is beneficial to promote symptoms remission and improve serum factors,with high safety.

关 键 词：吸入用布地奈德混悬液 硫酸特布他林雾化吸入用溶液 小儿毛细支气管炎 血清因子 安全性 

分 类 号：R725.6[医药卫生—儿科]