EB病毒感染伴发中性粒细胞减少患儿的临床特征及危险因素分析  

Clinical characteristics and risk factors analysis for children with Epstein-Barr virus infection accompanied by neutrophil granu-locytopenia

作　　者：杨璐 臧园园 刘畅 张振涛[1] YANG Lu;ZANG Yuanyuan;LIU Chang;ZHANG Zhentao(Department of Pediatric Medicine,Langfang People's Hospital,Langfang 065000,China)

机构地区：[1]廊坊市人民医院小儿内科,065000

出　　处：《浙江医学》2025年第3期290-294,共5页Zhejiang Medical Journal

基　　金：廊坊市科学技术研究与发展计划项目(2023013060)。

摘　　要：目的探讨人类疱疹(EB)病毒感染伴发中性粒细胞(NEU)减少患儿的临床特征及危险因素。方法回顾性选取2020年5月至2023年9月廊坊市人民医院收治的343例EB病毒感染患儿为研究对象,根据是否伴发NEU减少分为NEU减少组和对照组。比较两组患儿临床特征(一般资料、疾病及治疗资料)和实验室辅助检查资料,并采用多因素logistic回归分析EB病毒感染患儿伴发NEU减少的危险因素。结果343例患儿中伴发NEU减少47例,伴发率为13.70%。两组患儿年龄、高热占比、热程、EB病毒载量、抗病毒药物使用时间、红细胞沉降率比较,差异均有统计学意义(均P<0.05)。多因素logistic回归分析显示,年龄为1月龄~<3岁或3~6岁(OR=2.794、2.135)、热程长(OR=2.616)、EB病毒载量高(OR=3.024)、抗病毒药物使用时间>2周(OR=2.805)为EB病毒感染患儿伴发NEU减少的危险因素(均P<0.05)。结论年龄≤6岁、热程长、EB病毒载量高、抗病毒药物使用时间>2周和EB病毒感染患儿伴发NEU减少有关。故应对具有上述因素的EB病毒感染患儿加强观察,并制定妥善的预防措施,以预防NEU减少的发生。Objective To analyze the clinical characteristics and risk factors for children with Epstein-Barr(EB)virus infection accompanied by neutrophil(NEU)granulocytopenia.Methods A retrospective analysis was conducted on the data of 343 children with EB virus infection admitted to Langfang People's Hospital from May 2020 to September 2023.They were grouped into NEU granulocytopenia group and control group based on whether they were accompanied by NEU granulocytopenia.Clinical features(general information,diseases and treatment data)and laboratory auxiliary examination data were compared between the two groups,and multivariate logistic regression analysis was applied to analyze the risk factors for EB virus infection combined with NEU granulocytopenia.Results Forty-seven cases were accompanied by a decrease in NEU among 343 pediatric patients,with a concomitant rate of 13.70%.There were statistical differences between the NEU granulocytopenia group and the control group in terms of age,proportion of high fever,fever duration,EB virus load,and antiviral drug use time,erythrocyte sedimentation rate(all P<0.05).Multivariate logistic regression analysis showed that the risk factors for EB virus infection in children with NEU granulocytopenia mainly included age of one month-<3 years or 3-6 years(OR=2.794,and 2.135),long fever course(OR=2.616),high EB virus load(OR=3.024),and antiviral drug use time>2 weeks(OR=2.805)(all P<0.05).Conclusion Aged≤6 years,long fever course,high EB virus load,antiviral drug use time>2 weeks are related to NEU granulocytopenia in children with EB virus infection.Therefore,it is necessary to strengthen attention to EB virus infected children with the above factors and develop appropriate preventive measures to reduce the risk of NEU granulocytopenia.

关 键 词：EB病毒感染 中性粒细胞减少 临床特征 危险因素 

分 类 号：R72[医药卫生—儿科]