生物碱治疗类风湿关节炎的研究现状  

Research status of action of alkaloids in the treatment of rheumatoid arthritis

作　　者：李芸[1] 王玉辉 李莉[1] 马佳荣 赵敏[1] LI Yun;WANG Yu-hui;LI Li;MA Jia-rong;ZHAO Min(Gansu Pharmaceutical Industry Innovation Research Institute,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃中医药大学陇药产业创新研究院,甘肃兰州730000

出　　处：《中国临床药理学杂志》2025年第2期269-273,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82360773);甘肃省中药炮制技术传承基地建设基金资助项目。

摘　　要：类风湿关节炎(RA)是一种以多关节炎为主要表现的炎症性疾病。主要是由于免疫细胞引起的关节肿胀和关节炎症。中药中的生物碱可降低促炎因子水平和升高抗炎因子水平、减少关节滑膜组织增生、炎性细胞浸润和新生血管形成、抑制破骨细胞的分化,进而发挥抗RA作用。本文以生物碱治疗RA的作用及其机制进行综述,为治疗RA新药开发提供依据。Rheumatoid arthritis(RA)is an inflammatory disease mainly associated with polyarthritis.It is mainly due to the joint swelling and joint inflammation caused by immune cells.The alkaloids in traditional Chinese medicine can reduce the level of pro-inflammatory factors and increase the level of anti-inflammatory factors,reduce the joint synovial tissue hyperplasia,inflammatory cell infiltration and new blood vessel formation,inhibit the differentiation of osteoclasts,and then play an anti-RA role.Therefore,the review used the effects and mechanisms of alkaloids for RA to inform the development of new drugs for RA.

关 键 词：生物碱 类风湿关节炎 炎症 作用机制 研究现状 

分 类 号：R97[医药卫生—药品]