胰岛素抵抗机制及乌梅活性成分改善胰岛素抵抗的研究现状  

Research status of insulin resistance mechanisms and the improvement of insulin resistance by active ingredients of dark plum

作　　者：张珍妮 靳文芳 蒋虎刚 王新强 刘凯 李应东 赵信科 ZHANG Zhen-ni;JIN Wen-fang;JIANG Hu-gang;WANG Xin-qiang;LIU Kai;LI Ying-dong;ZHAO Xin-ke(School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Department of Cardiology,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730030,Gansu Province,China)

机构地区：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000 [2]甘肃中医药大学附属医院心血管科,甘肃兰州730030

出　　处：《中国临床药理学杂志》2025年第2期274-278,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家中医药管理局“李应东全国名中医传承工作室”建设基金资助项目(国中医药办人教函[2022]5号);甘肃省科技重大专项计划基金资助项目(20ZD7FA002);甘肃省中医药科研基金资助项目(GZKZD-2018-02,GZKP-2023-59);中医药传承与创新“百千万”人才工程(岐黄工程)青年岐黄学者基金资助项目(gzfy-2022-10);“双一流”科研重点基金资助项目(GSSYLXM-05);白银市科技计划基金资助项目(2022-2-50Y);甘肃中医药大学第三附属医院院内基金资助项目(2022YK-11)。

摘　　要：乌梅可用于虚热消渴、肺虚久咳等症,其活性成分具有辅助降血糖、抗菌消炎等作用。胰岛素抵抗以胰岛素在机体中的生理作用减弱为主,机制较复杂,可引发多种代谢相关性疾病,严重影响健康。乌梅活性成分可以通过调节胰岛素信号通路、调节内质网应激、抗氧化应激、调节炎症信号通路和相关炎症介质水平、游离脂肪酸水平等方面改善胰岛素抵抗。本文通过检索有关乌梅活性成分改善胰岛素抵抗的相关文献,对其作用机制进行总结分析,以期为胰岛素抵抗的深入研究和药物的开发应用提供新思路与科学依据。Dark plum can be used to treat symptoms such as consumptive thirst due to deficiency-heat and chronic cough due to lung deficiency.Its active ingredients have auxiliary effects on lowering blood glucose,antibacterial and anti-inflammatory activities.Insulin resistance is mainly characterized by the weakening of the physiological effects of insulin in the body,with a relatively complex mechanism that can lead to various metabolic-related diseases and seriously affect health.The active ingredients of dark plum can improve insulin resistance by regulating insulin signaling pathways,endoplasmic reticulum stress,antioxidant stress,inflammatory signaling pathways,levels of related inflammatory mediators,and free fatty acid levels.By reviewing the relevant literature on the improvement of insulin resistance by the active ingredients of dark plum,this article summarizes and analyzes its mechanism of action,aiming to provide new ideas and scientific evidence for in-depth research on insulin resistance and the development and application of drugs.

关 键 词：乌梅 活性成分 信号通路 应激反应 胰岛素抵抗 

分 类 号：R28[医药卫生—中药学]