糖萼降解与内皮细胞功能障碍关系的研究现状  

Research status of relationship between glycocalyx degradation and endothelial cell dysfunction

作　　者：卢国赐 徐星 刘凯 LU Guo-ci;XU Xing;LIU Kai(School of Traditional lChinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Departmentof Clinical Medicine,Gansu Medical College,Pingliang 744000,Gansu Province,China)

机构地区：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000 [2]甘肃医学院临床医学院,甘肃平凉744000

出　　处：《中国临床药理学杂志》2025年第2期284-289,共6页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金地区基金资助项目(82260869)。

摘　　要：糖萼(GC)是血管内皮细胞表面的重要组成部分,可以介导血管舒张、调节血管通透性、调节白细胞黏附以及抗炎等过程。在多种病理因素作用下,会诱导GC发生降解,从而通过多种机制引起氧化应激、炎症反应加剧、机械转导异常及白细胞黏附增多等病理过程介导内皮细胞功能障碍。此外,当内皮细胞功能障碍时,亦会导致GC降解加剧。本文对已发表的相关研究进行归纳分析,简述了GC降解与内皮细胞功能障碍之间存在的潜在关系以及相关药物干预研究,为后续开展相应药物研究提供了思路,也为提高临床相关疾病疗效做了铺垫。The glycocalyx(GC)constitutes an essential component of the vascular endothelial cell surface,facilitating vasodilation,regulating vascular permeability,modulating leukocyte adhesion,and exerting anti-inflammatory effects.Under the influence of diverse pathological factors,GC degradation is triggered,and endothelial cell dysfunction is mediated through various mechanisms such as oxidative stress,exacerbated inflammatory responses,abnormal mechanical transduction,and augmented white blood cell adhesion.Furthermore,dysfunctional endothelial cells can also lead to an intensification of GC degradation.In this paper,the potential correlation between GC degradation and endothelial cell dysfunction,along with related drug intervention studies,were summarized and analyzed,which provided ideas for subsequent drug research and pave the way for improving clinical efficacy of related diseases.

关 键 词：糖萼 内皮细胞功能障碍 炎症 氧化应激 机械转导 

分 类 号：R28[医药卫生—中药学]