Ki-67及CK5/6在不同年龄及超声BI-RADS分类乳腺癌中的表达情况分析  

Analysis of Ki-67 and CK5/6 Expression in Breast Cancer in Different Age and BI-RADS Grade

作　　者：唐敏[1] 宋建琼[1] 李雪 张婷婷 胡方源 Tang Min;Song Jianqiong;Li Xue;Zhang Tingting;Hu Fangyuan(Department of Ultrasound,Dazhou Central Hospital,Dazhou,Sichuan 635000,China;Department of Clinical Research Center,Dazhou Central Hospital,Dazhou,Sichuan 635000,China)

机构地区：[1]达州市中心医院超声医学科,四川省达州市635000 [2]达州市中心医院临床医学研究中心,四川省达州市635000

出　　处：《中国超声医学杂志》2025年第1期22-25,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的分析细胞周期调节蛋白-67(Ki-67)及细胞角蛋白5/6(CK5/6)在不同年龄及超声乳腺影像报告和数据系统(BI-RADS)乳腺癌中的表达情况。方法将677例乳腺癌患者共678个病灶的Ki-67、CK5/6表达结果与超声BI-RADS分类、患者年龄进行对比分析。结果BI-RADS不同分类中乳腺癌Ki-67及CK5/6表达结果差异均有统计学意义(P<0.05),且BI-RADS 3类乳腺癌中Ki-67高表达率及CK5/6阳性表达率均较高。不同年龄组乳腺癌Ki-67及CK5/6表达结果差异均无统计学意义(P>0.05)。二分类Logistic回归分析显示超声BI-RADS分类与Ki-67高表达及CK5/6阳性表达密切相关(P<0.05)。结论乳腺癌Ki-67及CK5/6表达与超声BI-RADS分类相关,与患者年龄无关。Objective To analyze the expression of cell cycle regulatory protein-67(Ki-67)and cytokeratin 5/6(CK5/6)in breast cancer in different age and different grade of breast imaging reporting data system(BI-RADS).Methods The expression of Ki-67 and CK5/6 in 677 breast cancer patients with 678 lesions were compared among different grade of BI-RADS classification and patients'age.Results There was significant difference in the expression of Ki-67 and CK5/6 in breast cancer of different BI-RADS grade(P<0.05),and the high expression rate in Ki-67 and positive expression rate in CK5/6 were both higher in breast cancer of BI-RADS grade 3.There was no significant difference in the expression of Ki-67 and CK5/6 in breast cancer among different age groups(P>0.05).Binary Logistic regression analysis showed that ultrasound BI-RADS grade was closely related to the high expression of Ki-67 and positive expression of CK5/6(P<0.05).Conclusions The expression of Ki-67 and CK5/6 in breast cancer is related to the ultrasonic BI-RADS,but not related to the patient's age.

关 键 词：乳腺癌 细胞周期调节蛋白-67 细胞角蛋白5/6 超声检查 乳腺影像报告和数据系统 年龄 

分 类 号：R73[医药卫生—肿瘤]