2016—2022年广东省人群华支睾吸虫感染流行病学和空间分布特征  

Epidemiological and spatial distribution characteristics of Clonorchis sinensis human infections in Guangdong Province from 2016 to 2022

作　　者：张官婷 张启明[1] 方悦怡[1] 裴福全[1] 毛强 刘佳慧 邓卓晖[1] 吴德[1] 卢文成[1] 刘珺[1] 廖宇煌 张嘉仪 陈经雕[1] ZHANG Guanting;ZHANG Qiming;FANG Yueyi;PEI Fuquan;MAO Qiang;LIU Jiahui;DENG Zhuohui;WU De;LU Wencheng;LIU Jun;LIAO Yuhuang;ZHANG Jiayi;CHEN Jingdiao(Guangdong Provincial Center for Disease Control and Prevention,Guangdong Workstation for Emerging Infectious Disease Control and Prevention,Guangzhou,Guangdong 511430,China)

机构地区：[1]广东省疾病预防控制中心、广东省新发突发传染病防治工作站,广东广州511430

出　　处：《中国血吸虫病防治杂志》2024年第6期584-590,共7页Chinese Journal of Schistosomiasis Control

基　　金：广东省新发传染病应急检测技术研究与应用重点实验室项目(2023B1212010010)。

摘　　要：目的分析2016—2022年广东省华支睾吸虫感染人群流行病学和空间分布特征,为当地制定华支睾吸虫病防治措施提供参考。方法2016—2022年,选取广东省江门市新会区、惠州市龙门县和韶关市翁源县等作为人群华支睾吸虫病固定监测点,另外每年选取10%~15%的华支睾吸虫病流行县(市、区)作为流动监测点。各监测点按照东、西、南、北、中5个地理方位,每个方位选取1个行政村(社区)随机抽取调查对象,采用Kato-Katz法检测调查对象粪样中华支睾吸虫虫卵,计算感染率和感染度,同时收集调查对象性别、年龄、民族、教育程度、职业等信息。于国家基础地理信息中心下载广东省1∶100万矢量电子地图,采用ArcGIS 10.7软件进行核密度分析、空间自相关分析等空间统计分析和可视化制图。结果2016—2022年,广东省累计对153188名居民进行华支睾吸虫感染调查,其中男性75596名(占49.35%),女性77592名(占50.65%);检出华支睾吸虫感染5369例,感染率为3.50%,其中重、中度和轻度感染者分别占0.76%、7.26%和91.97%。不同年龄、性别、民族、职业、文化程度人群华支睾吸虫感染率差异均有统计学意义(χ^(2)=2578.31、637.33、52.22、2893.28和1139.33,P均<0.05)。全局空间自相关分析发现,广东省人群华支睾吸虫感染率存在聚集性分布(Moran's I=0.63,Z=27.31,P<0.05);核密度分析发现,广东省人群华支睾吸虫感染率核密度高值主要分布于珠江三角洲地区珠江流域,其次分布于粤东地区和粤北地区;局部空间自相关分析发现73处华支睾吸虫感染率高-高聚集区。结论2016—2022年广东省人群华支睾吸虫感染率较高,且以轻度感染为主,具有空间聚集性;应对重点人群和区域有针对性地制定华支睾吸虫病防控措施。Objective To investigate the epidemiological characteristics and spatial distribution characteristics of Clonorchis sinensis human infections in Guangdong Province from 2016 to 2022,so as to provide insights into formulation of the clonorchiasis control measures in the province.Methods Xinhui District of Jiangmen City,Longmen County of Huizhou City and Wengyuan County of Shaoguan City in Guangdong Province were selected as fixed surveillance sites for human clonorchiasis from 2016 to 2022,and additional 10%to 15%counties(districts)endemic for clonorchiasis were sampled from Guangdong Province as mobile surveillance sites each year from 2016 to 2022.A village(community)was randomly selected from each surveillance site according to the geographical orientations of east,west,south,north and middle,and subjects were randomly sampled from each village(community).C.sinensis eggs were detected in subjects'stool samples using the Kato⁃Katz technique,and the prevalence and intensity of C.sinensis infections were calculated.In addition,subjects'gender,age,ethnicity,educational level and occupation were collected.The Guangdong Provincial 1∶1 million electronic map in vector format was downloaded from the National Geomatics Center of China,and kernel density analysis and spatial autocorrelation analysis of C.sinensis human infections in Guangdong Province from 2016 to 2022 were performed using the software ArcGIS 10.7.Results A total of 153188 residents were tested for C.sinensis infections in Guangdong Province from 2016 to 2022,including 75596 men(49.35%)and 77592 women(50.65%),and there were 5369 residents infected with C.sinensis,with 3.50%overall prevalence of infections.The prevalence rates of severe,moderate and mild C.sinensis infections were 0.76%,7.26%and 91.97%among C.sinensis⁃infected residents in Guangdong Province from 2016 to 2022,and there were age⁃,gender⁃,ethnicity⁃,occupation⁃and educational level⁃specific prevalence of C.sinensis human infections(χ^(2)=2578.31,637.33,52.22,2893.28 and 113

关 键 词：华支睾吸虫病 流行病学特征 空间聚集性 监测 广东省 

分 类 号：R532.23[医药卫生—内科学]