基于中性粒细胞胞外诱捕网异常堆积探讨清脾复卫法在胰腺癌治疗中的应用  

Exploring the Application of"Cleaning Spleen and Restoring Defensive Qi"Method in Treatment of Pancreatic Cancer based on Neutrophil Extracellular Traps Abnormal Accumulation

作　　者：张传龙 高梦琦 李奕 姜晓晨 寿松亭 庞博[3] 花宝金[3] ZHANG Chuanlong;GAO Mengqi;LI Yi;JIANG Xiaochen;SHOU Songting;PANG Bo;HUA Baojin(Beijing Friendship Hospital,Capital Medical University,Beijing,100050;Wangjing Hospital of China Academy of Chinese Medical Sciences;Guang′anmen Hospital,China Academy of Chinese Medical Sciences)

机构地区：[1]首都医科大学附属北京友谊医院,北京100050 [2]中国中医科学院望京医院 [3]中国中医科学院广安门医院

出　　处：《中医杂志》2025年第1期30-33,共4页Journal of Traditional Chinese Medicine

基　　金：北京市自然科学基金(7222296);北京市科学技术委员会首都临床诊疗技术研究及示范应用专项(Z191100006619022);中国中医科学院科技创新工程重大攻关项目(CI2021A01805);中国中医科学院博士研究生创新人才培养基金(2024)。

摘　　要：中性粒细胞胞外诱捕网(NETs)的异常堆积可以促进胰腺癌的发生、发展,NETs被认为是胰腺癌潜在的治疗靶点。《灵枢·口问》记载“卫气稽留”,基于卫气防御功能与中性粒细胞免疫功能相似的认识,结合中医理论与临床实践,提出NETs异常堆积或是“卫气稽留”的病理产物,病位关键在脾。进而探讨清脾复卫法在胰腺癌中的应用策略,提出运用通法以消脾滞、遏制胰腺癌细胞增殖,清法以除脾湿、抑制炎性微环境,补法以匡卫气、改善免疫微环境,以期为中医药治疗胰腺癌提供新思路。The abnormal accumulation of neutrophil extracellular traps(NETs)can promote the initiation and progression of pancreatic cancer,which is considered a potential therapeutic target for this disease.The Miraculous Pivot·Inquiry About Statement(《灵枢·口问》)have recorded the concept of"defensive qi stagnation".Based on the recognition that the function of defensive qi is similar to the immune function of neutrophils,and combining traditional Chinese medicine theory with clinical practice,it is proposed that the abnormal accumulation of NETs may be a pathological product of"defensive qi stagnation",with the spleen being the critical site of pathology.Further exploring the application strategy of cleaning spleen and restoring defensive qi method in pancreatic cancer treatment,it is proposed to employ three approaches such as dredging method to eliminate spleen stagnation and inhibit pancreatic cancer proliferation,cleaning method to remove spleen dampness and suppress the inflammatory micro-environment,and tonifying method to strengthen Weiqi and to improve the immune microenvironment,which aims to provide new insights for the clinical treatment of pancreatic cancer with traditional Chinese medicine.

关 键 词：胰腺癌 中性粒细胞胞外诱捕网 卫气稽留 清脾复卫 

分 类 号：R273[医药卫生—中西医结合]