暖宫调经汤口服联合八髎穴隔姜灸治疗阳虚宫寒型卵巢早衰患者65例临床观察  

Nuangong Tiaojing Decoction(暖宫调经汤)Combined with Ginger Moxibustion at Baliao(八髎)Acupoints for Patients with Premature Ovarian Failure of Yang-Deficiency Uterus-Coldeness Syndrome:65 Cases Clinical Observation

作　　者：孟昱琼 高强 翟婷婷 杨志虹 MENG Yuqiong;GAO Qiang;ZHAI Tingting;YANG Zhihong(The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang,550001;School of Acupuncture,Moxibustion and Tuina,Guizhou University of Traditional Chinese Medicine)

机构地区：[1]贵州中医药大学第一附属医院,贵州贵阳550001 [2]贵州中医药大学针灸推拿学院

出　　处：《中医杂志》2025年第1期59-64,共6页Journal of Traditional Chinese Medicine

基　　金：全国名中医传承工作室建设项目[国中医药班人教函[2022]245号];贵州中医药大学学术新苗项目(贵科合学术新苗[2023]-44号);贵州中医药大学大学生创新创业训练计划项目[贵中医大创合字[2023]73号]。

摘　　要：目的观察在西医常规治疗基础上应用暖宫调经汤口服及八髎穴隔姜灸治疗阳虚宫寒型卵巢早衰患者的临床疗效。方法130例阳虚宫寒型卵巢早衰患者根据患者意愿分为治疗组和对照组各65例。对照组给予西医常规治疗,治疗组在对照组治疗基础上予暖宫调经汤口服,每日1剂,同时进行八髎穴隔姜灸治疗,每日1次,两组均治疗3个月。治疗前后检测两组患者卵巢功能指标[包括卵巢体积、卵泡数量、卵巢收缩期峰值血流速度(PSV)、子宫内膜厚度]及血清性激素六项[孕酮(P)、雌二醇(E_(2))、卵泡刺激素(FSH)、黄体生成素(LH)水平与催乳素(PRL)和睾酮(T)]、抗苗勒管激素(AMH)水平,并于治疗前后比较两组患者中医证候积分(包括性欲减退、腰骶酸痛、畏寒肢冷、神疲乏力、面色晦暗、小腹胀痛、舌淡、脉沉涩评分)。治疗后判定临床疗效及安全性。结果与本组治疗前比较,两组治疗后卵巢体积、卵泡数量、PSV、子宫内膜厚度及P、E_(2)、AMH水平均明显升高,FSH、LH、PRL、T水平及腰骶酸痛、性欲减退、腰骶酸痛、性欲减退、面色晦暗、脉沉涩评分、中医证候积分均明显降低(P<0.05或P<0.01)。治疗组治疗后卵巢体积、卵泡数量、PSV、子宫内膜厚度及P、E_(2)、AMH水平均高于对照组,FSH、LH、PRL、T水平及各症状评分、中医证候积分明显低于对照组(P<0.05或P<0.01)。治疗组临床疗效总有效率为96.92%(63/65),对照组为81.54%(53/65),治疗组优于对照组(P<0.05)。治疗组不良反应发生率为26.15%(17/65),对照组为32.31%(21/65),两组比较差异无统计学意义(P>0.05)。结论在西医常规治疗基础上应用暖宫调经汤口服及八髎穴隔姜灸治疗阳虚宫寒型卵巢早衰可显著改善卵巢功能及临床症状,调节性激素水平,从而提高临床疗效。Objective To explore the clinical effectivess of Nuangong Tiaojing Decoction(暖宫调经汤)combined with ginger moxibustion at Baliao acupoints(Eight Bone-Holes)for treating premature ovarian failure(POF)of yangdeficiency uterus-coldeness syndrome,based on conventional western medical treatment.Methods A total of 130patients diagnosed with POF of yang-deficiency uterus-coldeness syndrome were divided into a treatment group and a control group,with 65 cases in each group,based on patient preference.The control group received conventional western medicine treatment,while the treatment group was additionally given Nuangong Tiaojing Decoction orally one dose per day and underwent ginger moxibustion at Baliao points once daily.Both groups were treated for three months.Before and after treatment,ovarian function indicators,including ovarian volume,follicle count,ovarian peak systolic velocity(PSV),and endometrial thickness were assessed,and serum sex hormone levels including progesterone(P),estradiol(E_2),follicle-stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),and testosterone(T),as well as anti-Müllerian hormone(AMH)levels were also measured.Additionally,traditional Chinese medicine(TCM)syndrome scores were evaluated,covering symptoms such as reduced libido,lumbosacral pain,fear of cold with cold extremities,fatigue,dull complexion,lower abdominal distension and pain,pale tongue,and deep and rough pulse.After treatment,clinical effectiveness and safety were determined.Results Compared with the pre-treatment levels within group,both groups showed significant increases in ovarian volume,follicle count,PSV,endometrial thickness,and levels of P,E_2,and AMH after treatment,while the levels of FSH,LH,PRL,and T,as well as scores of lumbosacral pain,reduced libido,dull complexion,deep and rough pulse,and total TCM syndrome scores significantly reduced after treatment.Furthermore,the treatment group exhibited higher ovarian volume,follicle count,PSV,endometrial thickness,and levels of P,E_2,and AMH compared

关 键 词：卵巢早衰 卵巢功能 性激素水平 隔姜灸 八髎穴 阳虚宫寒 暖宫调经汤 

分 类 号：R271.9[医药卫生—中西医结合]