社区老年人群运动功能与情绪和认知及睡眠的相关性研究  

Exploring the correlation between motor function and cognitive function,emotion and sleep in the Chinese community older adults

作　　者：刘玥滢 马欣昕[1] 杜宇 段晶晶 肖建红 林坚 黄雄昂[4] 刘超 王斌斌[6] 陈武君 邓婷 陈涛[3] 苏闻[1] Liu Yueying;Ma Xinxin;Du Yu;Duan Jingjing;Xiao Jianhong;Lin Jian;Huang Xiongang;Liu Chao;Wang Binbin;Chen Wujun;Deng Ting;Chen Tao;Su Wen(Department of Neurology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of GI Medical Oncology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin's Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China;Department of Neurology,Hainan General Hospital,Haikou 570311,China;Department of Neurology,Zhejiang Hospital,Hangzhou 300013,China;Digital Health China Technologies,Beijing 100080,China;Department of Neurology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;The First Dongguan Affiliated Hospital,Guangdong Medical University,Dongguan 523710,China)

机构地区：[1]北京医院神经内科、国家老年医学中心、中国医学科学院老年医学研究院、北京协和医学院、中国医学科学院,北京100730 [2]天津医科大学肿瘤医院消化肿瘤内科、国家恶性肿瘤临床医学研究中心、天津市恶性肿瘤临床医学研究中心、天津市肿瘤防治重点实验室,天津300060 [3]海南省人民医院神经科,海口570311 [4]浙江医院神经科,杭州300013 [5]神州医疗科技股份有限公司,北京100080 [6]南方医科大学南方医院神经科,广州510515 [7]广东医科大学附属东莞第一医院神经科,东莞523710

出　　处：《中华老年医学杂志》2025年第1期60-67,共8页Chinese Journal of Geriatrics

基　　金：国家重点研发计划(2020YFC2006404,2020YFC2006402,2020YFC2006400);国家重大疾病MDT合作诊疗能力建设项目(FTJ19-03);北京医院临床研究“领航”专项(BJ-2023-067)。

摘　　要：目的应用起立-行走计时测试(Timed Up and Go Test,TUGT)探究社区老年人群运动功能与情绪、认知、睡眠方面的相关性。方法横断面研究,2021年12月至2023年8月在中国北京市、天津市、浙江省、广东省、海南省随机招募60~90岁共739名受试者,根据TUGT时间(t),将受试者分为运动正常组、运动轻度异常组和运动明显异常组。收集基本信息,并应用TUGT评估运动功能,中国修订的简易智力状态检查量表(Mini-mental State Examination,MMSE)评估认知功能,患者健康问卷抑郁量表(Patient health questionnaire-9,PHQ-9)评估抑郁程度,Epworth嗜睡量表(Epworth Sleepiness Scale,ESS)评估过度日间嗜睡程度。分析受试者运动功能与认知、情绪及睡眠的相关性。结果收缩压、心率、PHQ-9、MMSE、ESS得分是TUGT时间的影响因素。TUGT时间与PHQ-9及ESS得分呈正相关,与收缩压、心率、MMSE得分呈负相关,与MMSE子成分中定向力、即刻记忆力及语言能力呈负相关,差异均具有统计学意义(均P<0.05)。logistic回归分析显示:PHQ-9得分升高(运动轻度异常组OR=1.099,95%CI:1.045~1.155,P<0.001;运动明显异常组OR=1.150,95%CI:1.066~1.242,P<0.001)、MMSE得分降低(运动轻度异常组OR=0.939,95%CI:0.886~0.995,P<0.033;运动明显异常组OR=0.793,95%CI:0.729~0.862,P<0.001)、ESS得分升高(运动轻度异常组OR=1.139,95%CI:1.094~1.186,P<0.001;运动明显异常组OR=1.203,95%CI:1.132~1.279,P<0.001)与运动功能下降独立相关。结论抑郁状态、认知障碍及过度日间嗜睡与社区老年人群运动功能下降具有相关性,TUGT可用于社区老年人群的运动功能下降的早期筛查。Objective To apply the Timed Up and Go Test(TUGT)to investigate the correlation between motor function,emotional state,cognitive function,and sleep quality among elderly individuals in the Chinese community.MethodsA cross-sectional study was conducted,involving 739 subjects aged 60 to 90 years,who were randomly recruited from December 2021 to August 2023 across Beijing,Tianjin,Zhejiang,Guangdong,and Hainan Provinces in China.Basic demographic information was collected,and the TUGT was utilized to assess motor function.Based on the TUGT time(t),the subjects were divided into three groups:normal motor function group,mild motor abnormality group,and significant motor abnormality group.Cognitive function was evaluated using the Chinese Revised Mini-Mental State Examination(MMSE),while the Patient Health Questionnaire Depression Scale(PHQ-9)was employed to measure the degree of depression.Additionally,the Epworth Sleepiness Scale(ESS)was used to assess excessive daytime sleepiness.The correlation between subjects'motor function and their cognitive abilities,mood,and sleep was subsequently analyzed.ResultsSystolic blood pressure,heart rate,PHQ-9,MMSE,and ESS scores were identified as significant factors influencing TUGT time.Specifically,TUGT time was positively correlated with PHQ-9 and ESS scores,while exhibiting negative correlations with systolic blood pressure,heart rate,and MMSE scores.Additionally,TUGT time was negatively correlated with the MMSE subcomponents of orientation,immediate memory,and verbal ability.All observed differences were statistically significant(all P<0.05).Logistic regression analysis indicated that an increase in the PHQ-9 score was associated with an odds ratio(OR)of 1.099(95%CI:1.045-1.155,P<0.001)(mild motor abnormality group)and 1.150(95%CI:1.066-1.242,P<0.001)(Significant motor abnormality group).Additionally,a reduction in the MMSE score was observed,with an OR of 0.939(95%CI:0.886-0.995,P<0.001)(mild motor abnormality group)and 0.793(95%CI:0.729-0.862,P<0.001)(Significant motor abnor

关 键 词：运动障碍 认知障碍 起立-行走计时测试 抑郁 过度日间嗜睡 

分 类 号：R74[医药卫生—神经病学与精神病学]