基于动态共价键的黏弹性可调复合水凝胶生物医学研究进展  

Biomedical Progress of Viscoelastic Tunable Composite Hydrogel Based on Dynamic Covalent Bonds

作　　者：张思琪 周昱如 刘冉 武晓刚 王艳芹 陈维毅 ZHANG Siqi;ZHOU Yuru;LIU Ran;WU Xiaogang;WANG Yanqin;CHEN Weiyi(College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China)

机构地区：[1]太原理工大学生物医学工程学院,太原030024

出　　处：《医用生物力学》2024年第6期1212-1220,共9页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(12372310);山西省自然科学基金项目(20210302123158);山西浙大新材料与化工研究院技术开发项目(2022SX-TD023);山西省本科生教育教学改革项目(J20230256)。

摘　　要：水凝胶具有良好的生物相容性以及与天然生物组织相似的力学性能,已广泛应用于生物医学领域。随着生物力学的发展,越来越多的研究发现,基于动态共价键构筑的黏弹性可调复合水凝胶,其优越的生物力学特性和刺激响应性,能更好模拟生物组织和天然细胞外基质随时间变化的黏弹性力学特性。本文详细总结基于不同类型的动态共价键(亚胺键、二硫键、硼酸酯键等)所构筑的黏弹性可调复合水凝胶在调控细胞功能、影响组织再生修复以及药物递送等领域的应用,并提出未来研究所面临的挑战与机遇。Due to good biocompatibility and mechanical properties similar to those of natural biological tissues,hydrogels have been widely used in biomedical fields.With the development of biomechanics,more and more researches have found that the viscoelastic tunable composite hydrogels based on dynamic covalent bonds can better simulate the viscoelastic mechanical properties of biological tissues and natural extracellular matrix over time due to their superior biomechanical properties and stimulus responsiveness.This review summarizes in detail the applications of viscoelastic tunable composite hydrogels based on different types of dynamic covalent bonds(imide bonds,disulfide bonds,borate ester bonds,etc.)in the fields of regulating cell function,affecting tissue regeneration and repair,as well as drug delivery.The challenges and opportunities for future research are also proposed.

关 键 词：复合水凝胶 动态共价键 黏弹性 应力松弛 细胞外基质 

分 类 号：R318.01[医药卫生—生物医学工程]