可生物降解氧化镁纳米颗粒用于低温保存缓解低温氧化损伤与机械损伤  

Biodegradable and Biocompatible MgO Nanoparticles as Antioxidants for Cryopreservation to Mitigate Oxidative and Mechanical Damage

作　　者：汪晓红 饶伟[1,2] WANG Xiaohong;RAO Wei(Key Laboratory of Cryogenics and Beijing Key Laboratory of CryoBiomedical Engineering,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China;School of Future Technology,University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]液态金属与低温生物医学研究中心,低温生物医学工程学北京市重点实验室,中国科学院理化技术研究所,北京100190 [2]中国科学院大学未来技术学院,北京100049

出　　处：《工程热物理学报》2025年第1期210-216,共7页Journal of Engineering Thermophysics

基　　金：中国科学院低温科学与技术全国重点实验室基础研究及前沿交叉项目(No.CRYO_(2)0230102)。

摘　　要：冷冻保存过程细胞的常见损伤有低温引起的冰晶机械损伤或氧化应激损伤,通常以分别添加抗冻保护剂或者抗氧化剂进行保护,缺乏可高效且同时减少这两类损伤的研究。本文利用绿色安全、可生物降解的氧化镁材料作为抑制细胞低温损伤和氧化损伤的保护材料,通过控制氧化镁在细胞内的传热传质,从生物和热物理两方面验证了氧化镁纳米颗粒具有强化传热和抗氧化的作用,有助于缓解细胞冻存过程中的氧化损伤和机械损伤,提高细胞无DMSO低温保存效率。本项工作有望为氧化镁材料在低温保存领域的研究提供新的思路。The common damages to cells during cryopreservation are ice crystal mechanical damage or oxidative stress damage caused by low temperatures.These damages are typically prevented by adding antifreeze protective agents or antioxidants,respectively.However,there is a lack of research focus on efficiently reducing these both types of damage simultaneously.In this paper,a green,safe,and biodegradable material,magnesium oxide,was used as a protective agent to inhibit cellular cryoprotection and oxidative damage.By regulating the heat and mass transfer of magnesium oxide within cells,it was confirmed that the magnesium oxide nanoparticles enhanced heat transfer and act as antioxidants from both biological and thermophysical perspective.This property could help to reduce oxidative and mechanical damage during cellular cryopreservation and enhance the effectiveness of DMSO-free cryopreservation.This work is expected to provide new ideas for the research of magnesium oxide materials in the field of cryopreservation.

关 键 词：氧化镁 生物降解 抗氧化 冰晶生长 低温保存 

分 类 号：TK123[动力工程及工程热物理—工程热物理]