针刺调控肠神经系统干预帕金森病的研究进展  

Research Progress of Acupuncture Regulating Enteric Nervous System in Parkinson's Disease

作　　者：徐珂 王顺[2] 白妍 王玉琳[2] 李元 张成光 史越 王天娇 张亚珂 XU Ke;WANG Shun;BAI Yan;WANG Yu-lin;LI Yuan;ZHANG Cheng-guang;SHI Yue;WANG Tian-jiao;ZHANG Ya-ke(Heilongjiang University of Traditional Chinese Medicine,Second Clinical Medical School,Harbin,150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin,150040,China;Heilongjiang Academy of Traditional Chinese Medicine,Institute of Acupuncture and moxibustion,Harbin,150000)

机构地区：[1]黑龙江中医药大学第二临床医学院,哈尔滨150040 [2]黑龙江中医药大学,哈尔滨150040 [3]黑龙江省中医药科学院针灸研究所,哈尔滨150000

出　　处：《针刺研究》2025年第1期110-115,共6页Acupuncture Research

基　　金：国家自然科学基金项目(No.81674091)。

摘　　要：帕金森病(PD)是一种常见于中老年人的神经系统变性疾病,发病率逐年增高。研究显示PD患者的肠神经系统(ENS)内一系列病理性级联反应所产生的病理产物经微生物-肠-脑轴中的迷走神经通路上行至大脑,最终导致PD的发生发展。针刺在调节ENS中的病理产物、恢复肠道微生物的生态平衡及延缓PD进程方面具有重要作用。本文就针刺干预PD患者或动物模型的肠道菌群、相关的微生物产物的生成、α-突触核蛋白、神经炎性反应及氧化应激等作用进行综述。Parkinson's disease(PD)isaneuro-degenerativediseasethat iscommon in middle-aged and elderly people,and its incidence is increasing year by year.Studies have shown that pathological products produced by a series of pathological cascade reactions in the enteric nervous system(ENS)of PD patients travel to the brain through the vagus nerve pathway in the microbial-gut-brain axis,and ultimately lead to the occurrence and development of PD.Acupuncture plays an important role in interfering with pathological products of ENS,restoring ecological balance of intestine and delaying PD process.In this paper,the effects of acupuncture on intestinal flora,production of related microbial products,α-synuclein,neuroinflammatory response and oxidative stress in patients or animal model with PD werereviewed.

关 键 词：针刺 帕金森病 肠神经系统 微生物-肠-脑轴 综述 

分 类 号：R246.6[医药卫生—针灸推拿学]