中医药调控细胞凋亡治疗非小细胞肺癌的研究现状  

Research status on traditional Chinese medicine regulating cell apoptosis for the treatment of non-small cell lung cancer

作　　者：孔思琪 传娟 李金田 梁建庆 张毅 KONG Si-qi;CHUAN Juan;LI Jin-tian;LIAN Jian-qing;ZHANG Yi(The Clinical College of Traditional Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;The Key Laboratory of The Ministry of Education f Dunhuang Medicine and Transformation,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]甘肃中医药大学敦煌医学与转化教育部重点实验室,甘肃兰州730000

出　　处：《中国临床药理学杂志》2025年第1期100-104,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82160872);甘肃省教育厅“双一流”科研重点基金资助项目(GSSYLXM-05);甘肃省中医药研究中心开放课题基金资助项目(zyzx-2020-zx17);中医学一级学科“岐黄英才”导师专项基金博导基金资助项目(ZYXKBD-202202)。

摘　　要：非小细胞肺癌(NSCLC)是肺癌总体构成中的最大部分,其发病率和死亡率居高不下。细胞凋亡是当前临床上治疗NSCLC的热点聚焦,其主要作用途径包括外源性死亡受体途径、内源性线粒体凋亡途径和内质网应激途径,共同调控机体的细胞凋亡过程。中医药在NSCLC治疗和预后方面具有疗效显著、扶助正气和药物不良反应少等优势。研究表明,多种中药单体和中药复方均可通过细胞凋亡途径治疗NSCLC,减轻放化疗后的药物不良反应。基于此,本文汇总近年来国内外文献,以细胞凋亡为切入点,总结中医药通过调控细胞凋亡治疗NSCLC的研究进展,以期为NSCLC临床治疗提供参考。Non-small cell lung cancer(NSCLC)constitutes the largest portion of lung cancer overall,with high incidence and mortality rates.Apoptosis,is a hot focus in the clinical treatment of NSCLC,its main pathways include the extrinsic death receptor pathway,intrinsic mitochondrial apoptosis pathway and endoplasmic reticulum stress pathway,collectively regulating the cellular apoptosis process.Traditional Chinese medicine(TCM)has significant efficacy in the treatment and prognosis of NSCLC,with advantages such as boosting the body’s resistance and less adverse drug reactions.Studies have shown that various individual Chinese herbal medicines and compound formulas can treat NSCLC through the apoptosis pathway,alleviating the adverse drug reaction of radiotherapy and chemotherapy.Based on this,this article summarizes recent domestic and international literature,focusing on apoptosis,to summarize the research progress of TCM in treating NSCLC by regulating apoptosis,aiming to provide reference for clinical treatment for NSCLC.

关 键 词：中医药 非小细胞肺癌 细胞凋亡 死亡受体途径 线粒体凋亡途径 内质网应激途径 

分 类 号：R28[医药卫生—中药学]