阿里红化学成分及其抗炎活性研究  

Chemical constituents from Fomes officinalis and their anti-inflammatory activities

作　　者：苏比努尔·居来提 许展鸣 刘宣麟 石磊岭 高兴旺[1] 郭雄飞 JULAITI Subinuer;XU Zhan-ming;LIU Xuan-lin;SHI Lei-ling;GAO Xing-wang;GUO Xiong-fei(College of Life Science and Technology,Xinjiang University,Urumqi 830017,China;Xinjiang Institute of Chinese and Ethnic Medicine,Urumqi 830002,China;Institute of Medicinal Plant Development,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100193,China;Xinjiang Institute of Pharmacy,Urumqi 830004,China)

机构地区：[1]新疆大学生命科学与技术学院,新疆乌鲁木齐830017 [2]新疆维吾尔自治区中药民族药研究所,新疆乌鲁木齐830002 [3]中国医学科学院北京协和医院药用植物研究所,北京100193 [4]新疆维吾尔自治区药物研究所,新疆乌鲁木齐830004

出　　处：《中成药》2025年第1期108-117,共10页Chinese Traditional Patent Medicine

基　　金：新疆维吾尔自治区自然科学基金(2021D01A169);新疆维吾尔自治区重大科技专项(2022A03019-4)。

摘　　要：目的研究阿里红Fomes officinalis(Vill.ex Fr.)Ames化学成分及其抗炎活性。方法阿里红95%乙醇提取物采用硅胶、Sephadex LH-20、HW-40C、MCI及半制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。采用RAW264.7模型评价其体外抗炎活性。结果从中分离得到20个化合物,分别鉴定为asperginine A(1)、落叶松脂酸(2)、methoxylaricinolic acid(3)、阿红酸(4)、19-acetoxy-13 S-hydroxylabda-8(17),14-diene(5)、bisbenzopyran(6)、乙酸落叶松脂酯(7)、fomitopsin G(8)、fomitopsin H(9)、demalonyl fomitopsin H(10)、fomlactone A(11)、fomlactone B(12)、阿里红醇A(13)、阿里红醇B(14)、laetiporins A(15)、laetiporins B(16)、去氢硫色多孔菌酸(17)、去氢齿孔酮酸(18)、3-酮基-去氢硫色多孔菌酸(19)、齿孔酸(20)。化合物7、13、20的IC 50值分别为(4.00±1.02)、(3.29±0.62)、(3.22±0.94)μmol/L。结论化合物1为新化合物,3、6、15、16为首次从该植物中分离得到。化合物7、13、20具有显著的抗炎活性。AIM To study the chemical constituents from Fomes officinalis(Vill.ex Fr.)Ames and their anti-inflammatory activities.METHODS The 95%ethanol extract from F.officinalis was isolated and purified by silica gel,Sephadex LH-20,HW-40C,MCI and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their anti-inflammatory activities in vitro were evaluated by RAW264.7 model.RESULTS Twenty compounds were isolated and identified as asperginine A(1),laricinolic acid(2),methoxylaricinolic acid(3),fomeffic acid(4),19-acetoxy-13 S-hydroxylabda-8(17),14-diene(5),bisbenzopyran(6),lariciresinol acetate(7),fomitopsin G(8),fomitopsin H(9),demalonyl fomitopsin H(10),fomlactone A(11),fomlactone B(12),fomefficinol A(13),fomefficinol B(14),laetiporins A(15),laetiporins B(16),dehydrosulphurenic acid(17),dehydroeburicoic acid(18),3-keto-dehydrosulfurenic acid(19),eburicoic acid(20).The IC 50 values of compounds 7,13,20 were(4.00±1.02),(3.29±0.62),(3.22±0.94)μmol/L,respectively.CONCLUSION Compound 1 is a new compound,3,6,15,16 are isolated from this plant for the first time.Compounds 7,13,20 have strong anti-inflammatory activities.

关 键 词：阿里红 化学成分 分离鉴定 抗炎活性 

分 类 号：R284.1[医药卫生—中药学]