五汁饮缓解干燥综合征口干症状临床观察  

Wuzhi Drink in Relieving Dry Mouth Symptoms of Sjögren’s Syndrome

作　　者：刘婷[1] 贾蝉忆 LIU Ting;JIA Chanyi(Department of Rheumatology,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院风湿病科,重庆400021

出　　处：《中国中医药现代远程教育》2025年第4期122-124,137,共4页Chinese Medicine Modern Distance Education of China

基　　金：重庆市科卫联合中医药技术创新与应用发展项目[No.2020ZY3603]。

摘　　要：目的 评价五汁饮缓解干燥综合征(SS)口干症状临床疗效。方法 选取在重庆市中医院就诊的SS患者58例,随机分为三组,均连续治疗12周。其中A组20例,口服硫酸羟氯喹片0.2 g,每天2次+五汁饮,每天3次,每次150 mL;B组19例,口服硫酸羟氯喹片0.2 g,每天2次+盐酸溴己新片8 mg,每天3次;C组19例,口服硫酸羟氯喹片0.2 g,每天2次。比较三组临床疗效、静态唾液流率、欧洲抗风湿联盟干燥综合征患者报告指数(ESSPRI)评分、舌背舌乳头萎缩程度、临床安全性。结果A组临床总有效率95.00%(19/20)高于B组的68.42%(13/19)和C组的63.16%(12/19)(P<0.05)。治疗后,三组患者静态唾液流率、ESSPRI评分较治疗前显著改善(P<0.05);治疗6周后,三组上述指标改善差异无统计学意义(P>0.05),但治疗12周后,A组患者上述指标与B、C两组比较,差异有统计学意义(P<0.05),B、C两组相关指标比较,差异无统计学意义(P>0.05)。在改善患者舌背舌乳头萎缩程度方面,三组差异均无统计学意义(P>0.05)。结论 五汁饮对缓解SS口干症状确有疗效,但在改善患者舌背舌乳头萎缩方面效果不显著。Objective To evaluate the clinical efficacy of Wuzhi drink in relieving dry mouth of Sjögren’s syndrome(SS).Methods Fifty-eight patients with SS in Chongqing Hospital of Traditional Chinese Medicine were randomly divided into three groups and treated for 12 weeks.Among them,20 cases in group A were given 0.2 g of hydroxychloroquine sulfate and Wuzhi drink,150 mL each time,3 times a day.Group B(19 cases)received oral administration of hydroxychloroquine sulfate 0.2 g,2 times a day and 8 mg bro-mohexine hydrochloride,3 times a day.A total of 19 patients in group C were given 0.2 g hydroxychloroquine sulfate orally,twice a day.The total clinical effective rate,static salivary flow rate,ESSPRI score,atrophy degree of tongue and tongue papilla of the back of tongue and safety of the three groups were compared.Results The total clinical effective rate of TCM syndrome in group A was 95.00%(19/20),which was higher than that in group B(68.42%,13/19)and group C(63.16%,12/19)(P<0.05).After treatment,the static sali-vary flow rate and ESSPRI score of the three groups were significantly improved compared with those before treatment(P<0.05).After 6 weeks of treatment,there was no statistically significant difference in the improvement of the above indicators among the three groups(P>0.05).However,after 12 weeks of treatment,there was statistically significant difference in the above indicators between group A and group B and group C(P<0.05).There was no statistically significant difference in the relevant indicators between group B and group C(P>0.05).There was no significant difference among the three groups in improving the atrophy degree of tongue papilla(P>0.05).Conclusion Wuzhi drink has a definite effect on relieving xerostomia of Sjögren’s syndrome,but it has no significant effect on improving the atrophy of the tongue back and the tongue nipple.

关 键 词：燥痹 干燥综合征 五汁饮 口干症状 中医药疗法 

分 类 号：R259[医药卫生—中西医结合]