金华地区2021—2023年梅毒感染孕产妇及其新生儿感染状况  

Prevalence survey of syphilis infection among puerpera and their newborn babies in Jinhua area from 2021 to 2023

作　　者：江渊 王晨 陈筱筱[1] 曹剑芳 JIANG Yuan;WANG Chen;CHEN Xiao-xiao;CAO Jian-fang(Jinhua Central Hospital,Jinhua,Zhejiang 321000,China;不详)

机构地区：[1]金华市中心医院皮肤科,浙江金华321000 [2]嘉兴市中医院皮肤科,浙江嘉兴314000 [3]金华市妇幼保健院孕产保健科,浙江金华321000

出　　处：《中华医院感染学杂志》2025年第2期245-249,共5页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生科技计划项目(2022KY1333);金华市科技局项目(2023-4-081)。

摘　　要：目的分析梅毒感染孕产妇的临床特征及其所生儿童梅毒感染状况,为临床制定相关干预政策提供参考依据。方法回顾性收集2021—2023年于金华地区各医院接受产检并分娩的604例梅毒感染孕产妇的个案信息,分析其梅毒感染情况、治疗情况、妊娠结局及新生儿情况等,多因素logistic回归模型分析梅毒感染孕产妇抗梅毒治疗的影响因素。结果604例梅毒感染孕产妇中586例(97.02%)接受抗梅毒治疗。多因素logistic回归分析结果显示,既往确诊梅毒[OR(95%CI):3.739(1.056~13.623)]、本次孕期确诊梅毒[OR(95%CI):6.542(2.124~20.144)]是金华地区梅毒感染孕产妇接受抗梅毒治疗的影响因素(P<0.05)。589例梅毒感染孕产妇成功分娩,分娩的602名新生儿中,接受预防性治疗542名(90.03%),经随访最终确诊先天梅毒7例(1.16%)。结论金华地区梅毒感染孕产妇接受抗梅毒治疗的比例较高,既往确诊梅毒、本次孕期确诊梅毒是孕产妇接受抗梅毒治疗的影响因素。临床应进一步加强梅毒早期筛查诊断,规范梅毒感染孕产妇及其新生儿的抗梅毒治疗,以控制先天梅毒的发生。OBJECTIVE To observe the clinical characteristics of the puerpera with syphilis infection and analyze the prevalence of syphilis infection among their newborn babies so as to provide bases for formulating related intervention measures.METHODS The case information was retrospectively collected from 604 puerpera with syphilis infection who received prenatal examination and gave birth in the hospitals of Jinhua area from 2021 to 2023.The prevalence rate of syphilis infection,treatment status,pregnancy outcomes and status of newborns were analyzed.Multivariate logistic regression model analysis was performed for influencing factors for the treatment of the puerpera with syphilis infection.RESULTS Among the 604 puerpera with syphilis infection,586(97.02%)received anti-syphilis treatment.The result of multivariate logistic regression analysis showed that previous history of syphilis infection[OR(95%CI):3.739(1.056 to 13.623)]and diagnosis as syphilis during the gestation[OR(95%CI):6.542(2.124 to 20.144)]were the influencing factors for the puerpera with syphilis infection to receive the anti-syphilis therapy(P<0.05).Totally 589 puerpera with syphilis infection were successfully delivered of healthy babies,542(90.03%)of 602 neonates received prophylactic treatment,and the follow-up showed that 7(1.16%)cases were finally diagnosed with prenatal syphilis.CONCLUSIONS The proportion of puerpera receiving the anti-syphilis therapy is high among the puerpera with syphilis infection in Jinhua area.Previous history of syphilis infection and diagnosis as syphilis infection during the gestation are the influencing factors for the puerpera with syphilis infection to receive anti-syphilis therapy.It is necessary for the hospital to further strengthen the screening and diagnosis of syphilis in early stage and normalize the anti-syphilis treatment of the puerpera with syphilis infection and their newborn babies so as to control the emergence of prenatal syphilis.

关 键 词：梅毒感染 妊娠梅毒 孕产妇 先天性梅毒 新生儿 

分 类 号：R715.3[医药卫生—妇产科学]