C型凝集素受体DC-SIGN及其在流感病毒感染中的研究进展  

Research advances in C-type lectin receptors DC-SIGN in influenza viral infections

作　　者：屠叶清 郑蕊 罗德炎 王慧 TU Yeqing;ZHENG Rui;LUO Deyan;WANG Hui(State Key Laboratory of Pathogen and Biosecurity,Insti-tute of Microbiology and Epidemiology,Academy of Military Medicine,Academy of Military Sciences,Beijing 100071,China;School of Basic Medical Sciences,Anhui Medical University,Hefei 230032,China)

机构地区：[1]军事科学院军事医学研究院微生物流行病研究所病原微生物生物安全国家重点实验室,北京100071 [2]安徽医科大学基础医学院,合肥230032

出　　处：《中国免疫学杂志》2025年第2期456-460,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(31870156)。

摘　　要：C型凝集素受体DC-SIGN是一类主要在树突状细胞表面表达的跨膜蛋白,其碳水化合物识别域可与多种病原体结合。近年随着人们对病毒感染免疫研究的深入,DC-SIGN在其中扮演的多方面作用逐渐被挖掘。作为一种模式识别分子,DC-SIGN在固有免疫应答、适应性免疫应答中均发挥重要作用,并可介导病毒顺式和反式感染。本文从DC-SIGN的结构与功能、表达与配体入手,介绍其在不同物种中的同源物,最后综述其在流感病毒感染中的作用,以期为研究和治疗DC-SIGN相关病毒感染提供新思路。C-type lectin receptors DC-SIGN is a transmembrane protein that mainly express on dendritic cell surface and its carbohydrate recognition domain can be combined with a variety of pathogens.In recent years,with deepening of research on viral infection immunity,multifaceted role played by DC-SIGN is gradually being mined.As a kind of pattern recognition molecules,DC-SIGN plays a crucial part in both innate and adaptive immune response,and can be mediated cis and trans viral infections.Starting with structure,function,expression and ligand of DC-SIGN,this review introduces molecular homologue in different species and finally summarizes role of DC-SIGN in influenza virus infections,which in order to find a new idea to study and treatment of viral infections associated with DC-SIGN.

关 键 词：C型凝集素 DC-SIGN(CD209) 流感病毒感染 

分 类 号：R392.11[医药卫生—免疫学] R37[医药卫生—基础医学]