TLR5在肥胖相关高血压发病机制中的作用:现有证据和未来挑战  

Role of TLR 5 in pathogenesis of obesity-related hypertension:Current evidence and future challenges

作　　者：吴欧 芈肖肖 张虎[4] 袁承达 高锦 WU Ou;MI Xiaoxiao;ZHANG Hu;YUAN Chengda;GAO Jin(Shulan International Medical College,Zhejiang Shuren University,Hangzhou 310015,China;Zhejiang Chinese Medical University Hangzhou 310053,China;The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310000,China;Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China;Guangxing Hospital Affiliated to Zhejiang Chinese Medical University/Hangzhou Traditional Chinese Medicine Hospital,Hangzhou 310007,China)

机构地区：[1]浙江树人学院树兰国际医学院,杭州310015 [2]浙江中医药大学,杭州310053 [3]杭州师范大学附属医院,杭州310000 [4]浙江大学附属邵逸夫医院,杭州310016 [5]浙江中医药大学附属广兴医院/杭州市中医院,杭州310007

出　　处：《中国免疫学杂志》2025年第2期484-489,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金资助项目(82100614)。

摘　　要：Toll样受体5(TLR5)是一种模式识别受体,是识别鞭毛蛋白的主要胞外受体,是连接固有免疫和适应性免疫的桥梁。其可以激活固有免疫,并诱导下游一系列细胞因子的释放,同时又在保护宿主免受鞭毛病原体侵害以及建立免疫耐受方面发挥了重要作用。这些功能都与肥胖性高血压的发生具有多方面关系。本文旨在综述TLR5与肥胖性高血压之间的关系,以及TLR5与鞭毛蛋白结构和功能的相互作用的新进展,并探讨未来的研究方向和挑战。Toll-like receptor 5(TLR5)is a pattern recognition receptor,the main extracellular receptor for recognizing flagellin,and a bridge between innate and adaptive immunity.It can activate innate immunity and induce the release of a series of downstream cytokines,as well as play an important role in protecting the host from flagellated pathogens and establishing immune tolerance.These functions are related to the pathogenesis of obesity hypertension in various aspects.This article aims to review the relationship between TLR5 and obese hypertension,as well as the new progress on the interaction between TLR5 and flagellin structure and function,and discuss the future research directions and challenges.

关 键 词：TOLL样受体5 高血压 肥胖 肠道菌群 免疫耐受 

分 类 号：R544.1[医药卫生—心血管疾病]