中药单体皂苷类调控免疫细胞抗肿瘤作用机制的研究进展  

Research progress on mechanism of monomeric saponins in Chinese herbal medicine in anti-tumor immunity

作　　者：赫名扬 王成志 张晓青[2] 李东东[1] 刘培民[1] HE Mingyang;WANG Chengzhi;ZHANG Xiaoqing;LI Dongdong;LIU Peimin(The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,China;The First Affiliated Hospital of Zheng-zhou University,Zhengzhou 450052,China)

机构地区：[1]河南中医药大学第二附属医院,郑州450002 [2]郑州大学第一附属医院,郑州450052

出　　处：《中国免疫学杂志》2025年第2期495-502,共8页Chinese Journal of Immunology

基　　金：国家自然科学基金资助项目(82204981);河南省中医药科学研究专项(2021JDZX2002,20-21ZY2115);河南省中医药大学2022年度研究生科研创新能力提升计划(2022KYCX057)。

摘　　要：恶性肿瘤的发病率和病死率持续增加,严重危害全球人群的身心健康,已成为急需解决的重大科学问题。肿瘤免疫治疗作为一种新型抗肿瘤治疗手段,优化了肿瘤的治疗模式,免疫联合化疗、靶向等治疗在抗肿瘤治疗方面具有良好效果。中医药在抗肿瘤综合治疗中应用广泛,中药单体皂苷类具有显著的抗肿瘤作用及高效低毒的明显优势,已成为当前众多肿瘤学者的研究热点。中药单体皂苷类通过调节机体固有免疫系统、适应性免疫系统以及相关免疫细胞因子,直接或间接影响免疫细胞功能,增强其对肿瘤细胞的免疫杀伤作用,发挥抗肿瘤作用。本文从中药单体皂苷类调节免疫细胞发挥抗肿瘤作用出发,总结其抗肿瘤作用的研究成果,以期为肿瘤免疫治疗提供新的研究思路,从而推动中医药现代化的发展进程。The incidence and mortality rates of malignant tumors continue to rise,which posing a serious threat to the physical and mental health of the global population,and becoming a significant scientific problem in urgent need of resolution.Tumor immunotherapy,as a novel anti-tumor treatment,optimizes the treatment modalities for tumors.Currently,combination of immunotherapy with chemotherapy and targeted therapy has shown promising results in anti-tumor treatment.Traditional Chinese medicine is widely used in comprehensive anti-tumor treatments,demonstrating significant effectiveness and distinct advantages.Among them,monomeric saponins in Chinese herbal medicine exhibit remarkable anti-tumor effects with the notable advantages of high efficiency and low tox-icity.This has made them a focal point of research for many oncologists.Studies have revealed that a large number of monomeric saponins from Chinese herbal medicine can directly or indirectly affect the functions of immune cells by regulating the innate immune system,adaptive immune system,and related immune cell factors.This enhances the immune cytotoxicity against tumor cells,thereby better exerting the anti-tumor immune effects.This paper summarizes the research findings on the anti-tumor effects of monomeric saponins in recent years.It elaborates on the specific mechanisms by which monomeric saponins from Chinese herbal medicine regulate immune cells to exert anti-tumor effects.The aim of this paper is to provide new research perspectives for tumor immunotherapy,further harness the crucial role of traditional Chinese medicine in anti-tumor treatment,and propel the modernization of traditional Chinese medicine.

关 键 词：皂苷类 免疫细胞 抗肿瘤 研究进展 

分 类 号：R285[医药卫生—中药学]