白癜风免疫发病机制的研究进展  

Research progress on immune pathogenesis of vitiligo

作　　者：李锴骁 胡雯[1] 康晓静[1] LI Kaixiao;HU Wen;KANG Xiaojing(Department of Dermatology and Venereology,People's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Clinical Research Center for Dermatologic Diseases,Xinjiang Key Laboratory of Dermatology Research,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院皮肤性病科,新疆皮肤病临床医学研究中心,新疆皮肤病研究重点实验室,乌鲁木齐830001

出　　处：《中国免疫学杂志》2025年第2期503-509,共7页Chinese Journal of Immunology

基　　金：国家自然科学基金(82173406)。

摘　　要：白癜风是一种色素脱失性皮肤病,由自体表皮黑素细胞的渐进性破坏引起。然而,造成黑素细胞功能障碍和死亡的机制尚不清楚。值得注意的是,白癜风患者的大部分黑素细胞死亡都是由自身免疫反应功能直接造成的,体内很多免疫相关细胞分子,如CD8+T细胞、IFN-γ、炎症细胞因子等,均在白癜风的发病机制中起到了一定作用。明确机体免疫、细胞因子、自身抗体等对黑素细胞正常功能的影响及在白癜风病情中所发挥的作用才能为找寻白癜风治疗方法提供依据。Vitiligo is a depigmentation skin disease caused by the progressive destruction of autologous epidermal melano‐cytes.However,the mechanism of melanocyte dysfunction and death is unclear.It is worth noting that most melanocyte deaths in patients with vitiligo are directly caused by autoimmune response.There are many immune related cell molecules in the body,such as CD8+T cells,IFN-γand inflammatory cytokines all play a role in the pathogenesis of vitiligo.To clarify the effects of body immunity,cytokines and autoantibodies on the normal function of melanocyte and their role in the condition of vitiligo can provide a basis for finding the treatment of vitiligo.

关 键 词：白癜风 发病机制 细胞免疫 体液免疫 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]