经典名方六磨汤关键信息考证及现代临床应用  

Textual Research on Key Information and Modern Clinical Application of Classical Famous Formula Liumotang

作　　者：张馨予 李冲 胡艺璇 梁路明 赵晔 鹿晓婷[1] 王钰 ZHANG Xinyu;LI Chong;HU Yixuan;LIANG Luming;ZHAO Ye;LU Xiaoting;WANG Yu(State Key Laboratory for Innovation and Transformation of Luobing Theory,Key Laboratory of Cardiovascular Remodeling and Function Research,Chinese Ministry of Education,Chinese National Health Commission and Chinese Academy of Medical Sciences,Qilu Hospital of Shandong University,Jinan 250012,China;College of Traditional Chinese Medicine(TCM),Shandong University of TCM,Jinan 250355,China;College of TCM,Hubei University of Chinese Medicine,Wuhan 430000,China;Pingyin People's Hospital,Jinan 250400,China)

机构地区：[1]山东大学齐鲁医院,络病理论创新转化全国重点实验室,心血管重构与功能研究重点实验室,教育部和国家卫健委重点实验室,济南250012 [2]山东中医药大学中医学院,济南250355 [3]湖北中医药大学中医学院,武汉430000 [4]平阴县人民医院,济南250400

出　　处：《中国实验方剂学杂志》2025年第3期201-212,共12页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81900397);山东大学横向基金项目[6010120057(032/2021横)]。

摘　　要：六磨汤出自元代《世医得效方》,由槟榔、沉香、木香、乌药、大黄及枳壳6味组成,是治疗气滞腹急,大便秘涩有热的经典名方。该研究系统整理古代医籍及现代临床文献中有关六磨汤的记载,深入分析与考证其处方出处、主治病证、组方、剂量、考证医籍、容器容量、炮制、制法服法、药物基原及组方方义等关键信息,以期为经典名方六磨汤的复方制剂研发与临床应用提供有力的参考。结果可知,六磨汤组方最早见于《世医得效方》,历代医籍多效仿于此;药物基原上,槟榔选用棕榈科植物槟榔Areca catechu的干燥成熟种子、沉香选用瑞香科植物白木香Aquilaria sinensis含有树脂的木材、木香选用菊科植物木香Aucklandia lappa的干燥根、乌药选用樟科植物乌药Lindera aggregata的干燥块根、大黄选用蓼科植物掌叶大黄R.palmatum、唐古特大黄R.tanguticum、药用大黄R.officinale的干燥根和根茎、枳壳选用芸香科柑橘属酸橙C.aurantium及其栽培变种的干燥未成熟果实;剂量上,通过对明清时期碗的考证,结合清代用药与碗容量的换算,推算元代时期每味药用量为10.86 g,明清时期药物用量多为等分,药物的用量有所变化;炮制与制法服法上,历代医籍中,药物的炮制略有改变,但用药皆选用生品,制法服法元明清时期变化不大,仅用量上存在一定的差异;主治病证上,六磨汤最早为治疗气滞腹急,大便秘涩有热而设,历代医籍中多遗漏有热之症,现代临床主要用于消化系统、泌尿系统疾病,多治疗便秘型肠易激综合征、胆汁反流性胃炎、功能性便秘及慢传输型便秘等病证,暂未发现有不良反应。上述研究结果为六磨汤复方制剂的研发及临床治疗提供可靠的科学依据。Liumotang comes from the Yuan dynasty's Effective Prescription Handed Down for Generations of Physicians.It is composed of six medicinal materials:Arecae Semen,Aquilariae Lignum Resinatum,Aucklandiae Radix,Linderae Radix,Rhei Radix et Rhizoma,and Aurantii Fructus.It is a classical formula for treating abdominal pain due to Qi stagnation and constipation accompanied by heat.This study systematically collated the records of Liumotang in ancient medical books and modern clinical literature and conducted in-depth analysis and textual research on its formula source,main diseases,composition,dosage,medical books,container capacity,processing,preparation method,usage,drug basis,formula meaning,and other key information,so as to provide a powerful reference for the development and clinical application of compound preparations of the classical formula Liumotang.The results show that Liumotang was first seen in Effective Prescription Handed Down for Generations of Physicians,and many medical books of the past dynasties have imitated this.In terms of drug basis,the dried and mature seeds of the palm plant Areca catechu,resin-containing wood of the Daphneaceae plant Aquilaria sinensis,the dried roots of the Asteraceae plant woody Aucklandia lappa,the dried tuber root of the Lauraceae plant Lindera aggregata,the dried roots and rhizomes of the knotweed plant,R.palmatum,R.tangutikum,and R.officinale,and the dried and unripe fruits of the citrus genus C.aurantium and its cultivated varieties from the family Rutaceae were selected.In terms of dosage,through the textual research on bowls in the Ming and Qing dynasties,combined with the conversion of medicines and bowl capacity in the Qing dynasty,it was estimated that the dosage of each drug in the Yuan dynasty was 10.86 g.In the Ming and Qing dynasties,the dosage of drugs was mostly equal,but the dosage of drugs was somewhat different.In terms of processing,preparation method,and usage,in the medical books of the past dynasties,the processing of drugs has slightly changed,but ra

关 键 词：经典名方 六磨汤 《世医得效方》 临床应用 文献研究 

分 类 号：G255[文化科学—图书馆学] R256[医药卫生—中医内科学] R289[医药卫生—中医学]