基于数据挖掘的脾虚湿盛证动物模型应用分析  

Analysis of Application of Animal Model of Spleen Deficiency and Dampness Syndrome Based on Data Mining

作　　者：于清茜 张翼飞 张泽涵 张炜悦[1] 王约博 吴凤芝[1] 李峰[1] YU Qingqian;ZHANG Yifei;ZHANG Zehan;ZHANG Weiyue;WANG Yuebo;WU Fengzhi;LI Feng(Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学,北京102488

出　　处：《中国实验方剂学杂志》2025年第3期235-243,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(81874428);国家自然科学基金青年基金项目(82204978)。

摘　　要：目的:研究脾虚湿盛证动物模型的造模方法、评价方法,为脾虚湿盛证动物模型的规范化提供参考。方法:通过检索脾虚湿盛证动物模型的文献,将符合纳排标准文献的发表时间、文献来源、动物情况、涉及病种、造模方法、造模时间、宏观证候评价指标、宏观量化指标、实验室检测指标、干预方式、阳性对照及应用情况等进行提取,建立数据库,进行定量统计、分析和可视化展示。结果:纳入符合标准的文献137篇。脾虚湿盛证动物模型的动物种类以SD大鼠为主。造模方法包括单因素法、双因素复合法及三因素复合法,各类模型广泛应用于药效验证与机制探讨研究。脾虚湿盛证动物模型评价指标主要包括宏观证候评价指标与宏观量化指标。实验室检测指标主要与水液代谢、胃肠功能等研究方向有关。当前研究涉及最多的方剂为参苓白术散和平胃散,最常用的阳性对照是自然恢复及使用西药柳氮磺嘧啶。结论:脾虚湿盛证动物模型的应用逐渐增多,已存在多种造模方式模拟脾虚湿盛证的典型特征,但仍存在许多值得思考与改进的地方。该研究为脾虚湿盛证动物模型证型名称规范、模型构建和评价体系的完善提供参考思路。Objective:The research focuses on developing modeling and evaluation methodologies for an animal model exhibiting spleen deficiency and dampness excess syndrome,with the aim of standardizing such animal models for future reference.Methods:By conducting a literature search on animal models of spleen deficiency and dampness excess syndrome,relevant publications meeting inclusion and exclusion criteria will be identified based on publication date,data source,types of diseases involved,animal characteristics,modeling methods,modeling duration,macroscopic syndrome assessment indicators,macroscopic quantification indicators,laboratory testing parameters,intervention approaches,positive controls and application context.A database will be established to facilitate the extraction of this information for quantitative analysis,statistical evaluation,and visual representation.Results:A total of 137 literature articles meeting the standards have been included in the research.The primary animal species used in animal models of spleen deficiency and dampness excess are SD rats.Modeling methods include single-factor,dual-factor composite,and triple-factor composite methods,with various models widely applied in validation of pharmacological effects and mechanistic explorations.Evaluation indices of animal models for spleen deficiency and dampness excess primarily consist of macroscopic syndrome evaluation indicators and macroscopic quantitative indicators.Laboratory testing indicators are mostly related to research areas such as fluid metabolism and gastrointestinal function.The most commonly studied herbal formulas currently include Shenling Baizhu San and Pingwei San,with natural recovery and the use of the western medicine metronidazole as the most frequently used positive controls.Conclusion:The application of animal models for spleen deficiency and dampness excess is gradually increasing,with various modeling methods already simulating the typical characteristics of this syndrome pattern.However,there are still many areas th

关 键 词：脾虚湿盛 动物模型 证候评价 数据挖掘 应用分析 

分 类 号：R285[医药卫生—中药学] R289[医药卫生—中医学] R287