基于中西医病证特点的慢性肾小球肾炎动物模型的临床吻合度分析  

Clinical Characteristics in Western Medicine and Traditional Chinese Medicine

作　　者：武思晴 郭琳[1,2] 张贝贝 苗明三[1,2] 苗晋鑫[1,2] WU Siqing;GUO Lin;ZHANG Beibei;MIAO Mingsan;MIAO Jinxin(Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-yao,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,郑州450046 [2]河南中医药大学豫药全产业链研发河南省协同创新中心,郑州450046

出　　处：《中国实验方剂学杂志》2025年第3期259-264,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省高校科技创新人才支持计划项目(23HASTTT045);国家中医药管理局岐黄学者支持项目(国中医药人教函2022-6);河南省重大公益专项(201300310100)。

摘　　要：慢性肾小球肾炎(CGN)是临床常见的自身免疫反应的慢性肾小球疾病,其发病机制复杂,且尚未被完全阐明。现代医学没有特异的治疗方法。建立符合中西医病证特点的CGN动物模型将有助于揭示CGN发病机制、药物评级及完善治疗方案。该文基于CGN临床诊断标准建立CGN中西医辨证标准,通过对CGN动物模型文献总结及分析归纳,发现CGN模型以大鼠为主造模,方法多为单因素诱导和双因素诱导,主要表现疾病特征是肾炎相关的症状。其中,单因素与双因素诱导CGN大鼠模型多具备较高的西医临床吻合度,但中医临床吻合度不足。此外,CGN中医证候模型以脾肾气虚证与肺肾气虚证为主,脾肾阳虚证、肝肾阴虚证和气阴两虚证模型稍不足。因此,制备新型及完善CGN动物模型,为CGN的中西医病证机制探索及治疗研究提供符合临床前模型。Chronic glomerulonephritis(CGN)is a common clinical chronic glomerular disease caused by autoimmune reaction,the pathogenesis of which is complex and has not been fully elucidated.There is no specific treatment method in modern medicine.The establishment of an animal model of CGN in accordance with its characteristics in western medicine and traditional Chinese medicine will help to reveal the pathogenesis of CGN,rate drugs,and improve the treatment plan.Based on the clinical diagnostic criteria of CGN,the paper establishes the syndrome differentiation criteria of CGN for Chinese and western medicine.Through summarizing the literature on animal models of CGN and making a further analysis,it is found that the CGN models are mainly modeled using rats with the methods of single-factor induction or two-factor induction,and the main manifestation of the disease characteristics is nephritis-related symptoms.The single-factor-induced or two-factor-induced CGN rat models have a high fitting degree with the clinical characteristics in western medicine,but the fitting degree is insufficient with the clinical characteristics in traditional Chinese medicine.In addition,the CGN models with syndromes of traditional Chinese medicine are dominated by Qi deficiency in the spleen and kidney and Qi deficiency in the lung and kidney,while models for Yang deficiency in the spleen and kidney,Yin deficiency in the liver and kidney,and deficiency of both Qi and Yin are slightly insufficient.Therefore,it is important to prepare a new and improved animal model of CGN,so that a preclinical model can be provided for the exploration of the pathogenesis of CGN in western medicine and traditional Chinese medicine and its therapeutic research.

关 键 词：慢性肾小球肾炎 临床吻合度 中西医病证特征 动物模型 

分 类 号：R289[医药卫生—方剂学] R692[医药卫生—中药学] R255[医药卫生—中医学]