糖尿病视网膜病变对神经节细胞-内丛状层厚度变化的影响  

Effect of diabetic retinopathy on the thickness of the ganglion cell-inner plexiform layer

作　　者：包莉 刘勤[2] 汪向利 白惠玲 BAO Li;LIU Qin;WANG Xiangli(First School of Clinical Medical,Gansu University of Chinese Medicine,Gansu,Lanzhou 730000,China;不详)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州市730000 [2]甘肃省人民医院眼科

出　　处：《河北医药》2025年第1期128-132,137,共6页Hebei Medical Journal

基　　金：甘肃省卫生行业科研计划项目(编号:GSWSKY-2019-40);甘肃省人民医院院内科研基金项目(编号:22GSSYD-42)。

摘　　要：糖尿病视网膜病变(diabetic retinopathy, DR)是一种早期会出现视网膜神经元细胞受损的疾病,能够导致黄斑区神经节细胞-内丛状层(ganglion cell-inner plexiform layer, GCIPL)的厚度变薄,导致患者视力下降。影响因素包括高血糖及代谢紊乱、氧化应激、谷氨酸的兴奋性毒性作用、炎症、视觉电生理改变等,及早评估GCIPL的改变,能给DR的早期病变以及DM早期视功能下降者提供帮助。本文对糖尿病视网膜GCIPL厚度改变的影响进行综述分析。Diabetic retinopathy(DR)is characterized by early damages to retinal neurons,leading to the thinning of the ganglion cell-inner plexiform layer(GCIPL)in the macular area and resulting in visual impairment.Influencing factors for DR include high blood sugar level,metabolic disorders,oxidative stress,excitotoxicity of glutamate,inflammation,and changes in visual electrophysiology.An early assessment of GCIPL changes can be helpful in detecting early DR lesions and visual function decline in patients with early diabetic maculopathy(DM).This article provided a comprehensive review and analysis of the impact of thickness changes in the GCIPL on DR.

关 键 词：糖尿病 糖尿病视网膜病变 神经节细胞-内丛状层 视网膜神经元 氧化应激 视觉电生理 

分 类 号：R587.25[医药卫生—内分泌]