消除乙型肝炎病毒危害:检验医学的“足”与“不足”  

Elimination of hepatitis B:what are the strengths and limitations of laboratory medicine

作　　者：欧启水[1] 傅亚[1] 刘灿[1] Ou Qishui;Fu Ya;Liu Can(Department of Laboratory Medicine,Fujian Key Laboratory of Laboratory Medicine,National Reginal Medical Center of Binhai Campus,Gene Diagnosis Research Center,the First Affiliated Hospital,Fujian Medical University,Fuzhou350005,China)

机构地区：[1]福建医科大学附属第一医院检验科、福建省检验医学重点实验室、福建医科大学附属第一医院滨海院区国家区域医疗中心福建医科大学基因诊断研究中心,福州350005

出　　处：《中华检验医学杂志》2025年第1期1-7,共7页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(82202596,82372316,82172338,82272420)。

摘　　要：检验医学对乙型肝炎病毒(HBV)感染的诊断十分重要,其检测项目主要包括HBV标志物和肝病进程诊断标志物。HBV标志物可分为经典HBV标志物和新型HBV标志物。由HBV感染引起的肝病进程诊断标志物主要涉及肝炎、肝纤维化和肝癌的诊断。目前,检验医学在慢性HBV感染诊疗中仍存在一些需进一步探讨的问题,明确这些问题有助于实现“在我国范围内消除乙型肝炎作为公共卫生危害”的目标。该文对HBV标志物和肝病进程诊断标志物的研究进展和临床应用情况(检验医学的“足”)进行了总结,同时针对“消除乙型肝炎危害”这一目标,对检验医学提出的新要求(检验医学的“不足”)进行了一些思考,就检验医学在消除乙型肝炎中的“足”与“不足”作一述评,供临床和检验医师参考。Laboratory medicine plays a crucial role in the diagnosis of hepatitis B virus(HBV)infection,primarily through the detection of HBV markers and diagnostic markers of liver disease progression.HBV markers can be categorized into classical and novel types.Diagnostic markers of liver disease progression related to HBV infection are mainly associated with hepatitis,liver fibrosis,and liver cancer.Currently,there are unresolved issues in laboratory medicine regarding the management of chronic HBV infection.Addressing these issues is essential to achieve the goal of"eliminating hepatitis B related public health threat in our country".This article summarizes the research progress and clinical applications of HBV markers and liver disease progression diagnostic markers(the"strengths"of laboratory medicine),while also contemplates the new requirements posed by the elimination of hepatitis B on laboratory medicine(the"limitations").A commentary on the"strengths"and"limitations"of laboratory medicine in the context of hepatitis B elimination is provided for reference by clinicians and laboratory professionals.

关 键 词：临床实验室技术 乙型肝炎病毒 慢性乙型肝炎 生物标志物 

分 类 号：R512.62[医药卫生—内科学] R446[医药卫生—临床医学]