肝脏巨噬细胞在慢性乙型肝炎病毒感染中的研究进展  

Research progress on the role and mechanism of liver macrophages in chronic hepatitis B virus infection

作　　者：郭鸿燕 傅亚[1] 欧启水[1] Guo Hongyan;Fu Ya;Ou Qishui(Department of Laboratory Medicine,Fujian Key Laboratory of Laboratory Medicine,National Reginal Medicine Center of Binhai Campus,Gene Diagnosis Research Center,the First Affiliated Hospital,Fujian Medical University,Fuzhou350005,China)

机构地区：[1]福建医科大学附属第一医院检验科、福建省检验医学重点实验室、福建医科大学附属第一医院滨海院区国家区域医疗中心、福建医科大学基因诊断研究中心,福州350005

出　　处：《中华检验医学杂志》2025年第1期153-158,共6页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(82202596,82372316,82030063)。

摘　　要：肝脏巨噬细胞是肝脏固有免疫的关键成员,其在慢性乙型肝炎病毒(HBV)感染中发挥重要作用。受肝脏微环境影响,肝脏巨噬细胞可表现出不同的免疫表型和功能,具有抑制HBV感染和介导免疫耐受的双重作用。HBV也可主动调控肝脏巨噬细胞表型,从而有利于病毒持续感染。鉴于肝脏巨噬细胞和HBV间的相互作用直接影响HBV感染的结局,并且靶向巨噬细胞的标志物具有潜在的临床实践价值,因此,该文将从肝脏巨噬细胞的来源与异质性、肝脏巨噬细胞与HBV之间的相互作用,以及巨噬细胞相关的HBV感染潜在免疫学血清标志物三个方面,阐述肝脏巨噬细胞在HBV感染中的研究进展。Liver macrophages are crucial components of innate immune system in liver and play a pivotal role in chronic hepatitis B virus(HBV)infection.Influenced by the liver microenvironment,liver macrophages can exhibit diverse immunophenotypes and functions,which contribute to either inhibiting HBV infection or mediating immune tolerance.Additionally,HBV actively regulates the phenotype of liver macrophages,thereby facilitating continuous viral infection.Given that the interaction between liver macrophages and HBV might directly impact the outcome of HBV infection,the huge potential clinical value of targeting macrophage markers,this review highlights the research progress on liver macrophages in HBV infection from three aspects:the origin and heterogeneity of liver macrophages,the interaction between liver macrophages and HBV,and the potential serological immune markers associated with macrophages in HBV infection.

关 键 词：乙型肝炎病毒 肝巨噬细胞 免疫微环境 免疫学血清标志物 

分 类 号：R512.62[医药卫生—内科学]