CT引导下脊髓背根神经节脉冲射频联合臭氧治疗慢性带状疱疹后神经痛的临床疗效  

Clinical curative effect of CT-guided dorsal root ganglion pulsed radiofrequency combined with ozone injection for chronic postherpetic neuralgia

作　　者：王桂岭 王春满 李琳[1] 高谦[1] 杜传随 WANG Guiling;WANG Chunman;LI Lin;GAO Qian;DU Chuansui(Pain Management,Hengshui Municipal People′s Hospital(Harrison International Peace Hospital),Hengshui,Hebei Province 053000,China)

机构地区：[1]衡水市人民医院(哈励逊国际和平医院)疼痛科,河北衡水053000

出　　处：《介入放射学杂志》2024年第12期1330-1334,共5页Journal of Interventional Radiology

基　　金：2023年度河北省医学科学研究课题计划(20232174)。

摘　　要：目的分析慢性带状疱疹后神经痛(postherpetic neuralgia,PHN)患者接受CT引导下脊髓背根神经节脉冲射频(DRG-PRF)联合臭氧治疗的效果。方法选取2020年12月至2023年8月衡水市人民医院收治的慢性PHN患者300例,根据随机数字表法分为观察组150例,对照组150例。对照组予以臭氧治疗,观察组联合CT引导下DRG-PRF。比较两组疗效、治疗前后红外热成像指标[皮损区域及对应健侧区域皮肤温差(ΔT)]、睡眠质量、疼痛程度及炎症因子[前列腺素E2(PGE2)、P物质(SP)、白细胞介素-6(IL-6)、IL-1β]。结果观察组总有效率为92.67%(139/150),高于对照组的83.33%(125/150),差异有统计学意义(P<0.05)。治疗后1 d、3 d、7 d、1个月、3个月,观察组ΔT、PSQI评分、NRS评分均低于对照组,差异有统计学意义(P<0.05)。观察组血清PGE2、SP、IL-6、IL-1β低于对照组,差异有统计学意义(P<0.05)。结论CT引导下DRG-PRF联合臭氧治疗PHN的疗效确切,能有效促进患者皮损区域恢复,提高睡眠质量,缓解疼痛,调节疼痛及炎症因子水平。Objective To evaluate the clinical curative effect of CT-guided dorsal root ganglion pulsed radiofrequency(DRG-PRF)combined with ozone injection in treating patients with chronic postherpetic neuralgia(PHN).Methods A total of 300 patients with chronic PHN,who were admitted to the Hengshui Municipal People′s Hospital of China from December 2020 to August 2023,were enrolled in this study.Using random digital table method,the patients were divided into observation group(n=150,receiving ozone injection+CT-guided DRG-PRF)and control group(n=150,receiving ozone injection alone).The curative effect,infrared thermal imaging index(skin temperature difference between skin lesion area and the corresponding healthy side,i.e.ΔT),sleep quality,pain degree(determined by numerical rating scale,NRS),and pain/inflammatory factors including prostaglandin E2(PGE2),substance P(SP),interleukin-6(IL-6),interleukin-1β(IL-1β)were compared between the two groups.Results The total response rate in the observation group was 92.67%(139/150),which was higher than 83.33%(125/150)in the control group,the difference was statistically significant(P<0.05).At one d,3 d,7 d,one month and 3 months after treatment,the scores ofΔT,PSQI and NRS in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The levels of serum PGE2,SP,IL-6 and IL-1βin the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion For the treatment of chronic PHN,CT-guided DRG-PRF combined with ozone injection has reliable clinical effect,it can effectively promote the recovery of skin damage,improve sleep quality,relieve pain,and regulate the levels of pain and inflammatory factors.

关 键 词：带状疱疹后神经痛 CT引导 脊髓背根神经节脉冲射频联 臭氧 临床疗效 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]