冻融胚胎行激光辅助孵化后移植对妊娠结局的影响  

Effect of Laser-Assisted Hatching-Assisted Transfer of Freeze-Thaw Embryos on Pregnancy Outcomes

作　　者：季海波 张其峰 杨宇 JI Haibo;ZHANG Qifeng;YANG Yu(Reproductive Medicine Center,the First Hospital of Qiqihar,Qiqihar 161000,China)

机构地区：[1]齐齐哈尔市第一医院生殖医学中心,黑龙江齐齐哈尔161000

出　　处：《反射疗法与康复医学》2024年第20期43-46,50,共5页Reflexology And Rehabilitation Medicine

基　　金：齐齐哈尔市科技计划创新激励项目(CSFGG-2023038)。

摘　　要：目的分析冻融胚胎行激光辅助孵化(LAH)后移植对妊娠结局的影响。方法回顾性分析2022年1月—2023年1月于齐齐哈尔市第一医院行冻融胚胎移植治疗的369例不孕患者的临床资料,根据是否行LAH将其分为LAH组(n=199)和未行LAH(Non-LAH)组(n=170)。比较两组患者的胚胎解冻复苏率、胚胎情况、胚胎移植情况及子代出生情况。结果LAH组的胚胎解冻复苏率为96.48%,高于Non-LAH组的87.64%,移植胚胎数为(2.39±0.12),多于NonLAH组的(2.25±0.09),组间差异有统计学意义(P<0.05);两组的优质囊胚率比较,差异无统计学意义(P>0.05)。LAH组的胚胎着床率、移植周期妊娠率、活产率分别为98.44%、94.71%、94.38%,均高于Non-LAH组的87.92%、84.73%、81.98%,流产率为5.62%,低于Non-LAH组的18.02%,组间差异有统计学意义(P<0.05)。两组出生缺陷率及早产率比较,组间差异无统计学意义(P>0.05)。结论冻融胚胎行LAH后移植可提高胚胎解冻复苏率,改善胚胎情况及移植情况,帮助患者获得更好的妊娠结局。Objective To analyze the effect of laser-assisted hatching(LAH)of freeze-thaw embryos on pregnancy outcomes.Methods The clinical data of 369 infertile patients treated with freeze-thaw embryo transfer in the First Hospital of Qiqihar from January 2022 to January 2023 were retrospectively analyzed,they were divided into the LAH group(199 cases)and the non-LAH group(170 cases)according to whether or not they underwent LAH.The embryo thawing recovery rate,embryo status,embryo transfer status and progeny birth status of the two groups were compared.Results The embryo thawing recovery rate in the LAH group was 96.48%,which was higher than 87.64%in the non-LAH group,and the number of embryos transferred was(2.39±0.12),which was higher than(2.25±0.09)in the non-LAH group,the differences between the groups were statistically significant(P<0.05);there was no significant difference in the high-quality blastocyst rate between the two groups(P>0.05).The implantation rate,pregnancy rate and live birth rate of the LAH group were 98.44%,94.71%and 94.38%,respectively,which was higher than 87.92%,84.73%and 81.98%in the non-LAH group,and the abortion rate was 5.62%,which was lower than 18.02%in the non-LAH group,the differences between the groups were statistically significant(P<0.05).The rates of birth defects and preterm birth were compared between the two groups,there were no significant differences between groups(P>0.05).Conclusion Transfer of freeze-thaw embryos after LAH can improve the thawing recovery rate of embryos,improve the condition of embryos and transfer,and help patients obtain better pregnancy outcomes.

关 键 词：冻融胚胎 激光辅助孵化 移植 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]