在全膝关节置换术中联合氨甲环酸治疗膝关节骨性关节炎患者的临床效果观察  

Observation on the Clinical Effect of Tranexamic Acid Combined with Total Knee Arthroplasty in the Treatment of Patients with Knee Osteoarthritis

作　　者：郭洪卫 GUO Hongwei(Department of Joint Surgery,Zibo City Hospital of Traditional Chinese Medicine,Zibo 255000,China)

机构地区：[1]淄博市中医医院关节外科,山东淄博255000

出　　处：《反射疗法与康复医学》2024年第20期102-105,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨在全膝关节置换术中联合氨甲环酸治疗膝关节骨性关节炎患者的临床效果。方法选取2021年1月—2023年10月淄博市中医医院收治的84例膝关节骨性关节炎患者为研究对象,按随机数字表法将其分为对照组和观察组,每组42例。对照组行全膝关节置换术治疗,观察组在全膝关节置换术中联合氨甲环酸治疗。对比两组的手术情况、疼痛程度、血液指标、炎症水平、肢体运动功能、膝关节功能。结果术前,两组疼痛程度、血液指标、炎症水平、肢体运动功能、膝关节功能对比,组间差异无统计学意义(P>0.05);两组手术时间对比,差异无统计学意义(P>0.05);观察组住院时间短于对照组,术中出血量、术后引流量均少于对照组,组间差异有统计学意义(P<0.05);术后6 h、48 h,观察组疼痛视觉模拟评分为(4.12±0.48)分、(3.04±0.35)分,低于对照组的(4.89±0.52)分、(3.76±0.38)分,组间差异有统计学意义(P<0.05);术后3 d,观察组血红蛋白、红细胞压积水平均高于对照组,C反应蛋白、肿瘤坏死因子-α水平均低于对照组,组间差异有统计学意义(P<0.05);术后3个月,两组Fugl-Meyer下肢运动功能评定量表、西安大略和麦克马斯特大学骨关节炎调查量表评分对比,组间差异无统计学意义(P>0.05)。结论在全膝关节置换术中联合氨甲环酸治疗可缩短膝关节骨性关节炎患者住院时间,减轻其局部疼痛,降低炎症水平,有利于关节功能恢复,值得广泛应用。Objective To explore the clinical effect of tranexamic acid combined with total knee arthroplasty in the treatment of patients with knee osteoarthritis.Methods A total of 84 patients with knee osteoarthritis treated in Zibo City Hospital of Traditional Chinese Medicine from January 2021 to October 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 42 cases in each group.The control group was treated with total knee arthroplasty,while the observation group was treated with tranexamic acid combined with in total knee arthroplasty.The operation condition,pain degree,blood indicators,inflammation level,limb motor function and knee joint function were compared between the two groups.Results Before the operation,the pain degree,blood indexes,inflammation level,limb motor function and knee joint function of the two groups were compared,and the differences between the groups were not statistically significant(P>0.05);comparison of operation time between the two groups,and the difference was not statistically significant(P>0.05);the duration of hospitalization in the observation group was shorter than that in the control group,the amount of intraoperative blood loss and postoperative drainage volume were less than that in the control group,and the differences between the groups were statistically significant(P<0.05);after 6 and 48 hours,the scores of Visual Analogue Scale for pain in the observation group were(4.12±0.48)points and(3.04±0.35)points,which were lower than(4.89±0.52)points and(3.76±0.38)points of the control group,and the differences between the groups were statistically significant(P<0.05);three days after operation,the average levels of hemoglobin and hematocrit in the observation group were higher than those in the control group,C-reactive protein and tumor necrosis factor-αwere lower than those in the control group,and the differences between the groups were statistically significant(P<0.05);three mont

关 键 词：膝关节骨性关节炎 氨甲环酸 全膝关节置换术 疼痛程度 肢体运动功能 

分 类 号：R684.3[医药卫生—骨科学]