COPD急性加重期患者中医证型与血清miR-183、IL-17、IL-33及sST2水平相关性研究  

Correlation between Chinese medicine patterns andserum miR-183,IL-17,IL-33 and sST2 levels in patients with acute exacerbation of COPD and sST2 levels in patients with acute exacerbation of COPD

作　　者：张小波 龙小龙 郑守梁 ZHANG Xiaobo;LONG Xiaolong;ZHENG Shouliang(Yongchang Town Central Health Center,Beichuan Qiang Autonomous County,Mianyang,Sichuan 622750,China)

机构地区：[1]北川羌族自治县永昌镇中心卫生院,四川绵阳622750

出　　处：《四川中医》2025年第1期121-125,共5页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者中医证型与血清miRNA-183(miR-183)、白细胞介素-17(IL-17)、IL-33及可溶性人基质裂解素2(sST2)水平的相关性。方法:选取本院2022年1月~2023年12月收治的92例AECOPD患者为研究组,并选同期健康体检者83名作为对照组,检测对比两组的血清miR-183、IL-17、IL-33及sST2水平。另参照《中医内科学》及《慢性阻塞性肺疾病中医诊疗指南》判定研究组患者的中医证型,并分成痰热郁肺证、痰浊壅肺证、肺肾气虚证三组,检测对比不同中医证型患者的肺功能及miR-183、IL-17、IL-33、sST2水平的差异。结果:与对照组相比,研究组的miR-183、IL-17、IL-33及sST2水平均更高,差异有统计学意义(P<0.05)。92例AECOPD患者中痰热郁肺证33例、痰浊壅肺证28例、肺肾气虚证31例,肺肾两虚证的第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占预计值百分比(FEV1%)均低于痰热郁肺证、痰浊壅肺证(P<0.05),三种中医证型的第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC)对比无显著差异(P>0.05);肺肾气虚证的血清miR-183、IL-17、IL-33及sST2水平均高于痰浊壅肺证、痰热郁肺证,且痰热郁肺证以上指标均高于痰浊壅肺证(P<0.05)。结论:AECOPD患者血清miR-183、IL-17、IL-33及sST2水平均与中医证型存在一定的相关性,可作为中医辨证分型的辅助工具。Objective:To investigate the correlation between Chinese medicine patterns and serum miRNA-183(miR-183),interleukin-17(IL-17),IL-33 and soluble human stromal lysin 2(sST2)levels in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Ninety-two AECOPD patients admitted to our hospital from January 2022 to December 2023 were selected as the study group,and 83 healthy medical checkups during the same period were selected as the control group,and serum miR-183,IL-17,IL-33 and sST2 levels of the two groups were tested and compared.The patients in the study group were categorized into three groups:phlegm-heat lung syndrome,phlegm-fluid lung syndrome,and lung-kidney qi deficiency syndrome,with reference to the“Internal Medicine of Traditional Chinese Medicine”and the“Guidelines for the Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease in Traditional Chinese Medicine”.Tests were performed to compare the differences in lung function and levels of miR-183,IL-17,IL-33,and sST2 in patients with different TCM certificates.Results:Compared with the control group,the levels of miR-183,IL-17,IL-33and sST2 were higher in the study group,and the difference was statistically significant(P<0.05).Among the 92 patients with AECOPD,there were 33 cases of phlegm-heat lung syndrome,28 cases of phlegm-heat lung syndrome,and 31 cases of lung and kidney qi deficiency syndrome.The first second expiratory volume with exertion(FEV1)and the first second expiratory volume with exertion as a percentage of predicted value(FEV1%)were lower in the Lung and Kidney deficiency syndrome than in the Phlegm-Heat-Depression of Lungs and Phlegm-Turbidity-Congestion of Lungs syndromes(P<0.05),and there was no significant difference in the comparison of first second expiratory volume with exertion as a percentage of exerted lung capacity(FEV1/FVC)among the three Chinese medicine syndromes(P>0.05).Serum miR-183,IL-17,IL-33 and sST2 levels were higher in the Lung and Kidney Qi Deficiency syndrome than

关 键 词：慢性阻塞性肺疾病急性加重期 中医证型 miRNA-183 白细胞介素-17 白细胞介素-33 可溶性人基质裂解素2 

分 类 号：R256.1[医药卫生—中医内科学]