低分子量肝素钠联合小剂量阿司匹林治疗胎儿生长受限的效果及对孕妇羊水指数、凝血功能的影响研究  

Study on the effect of low-molecular-weight heparin sodium combined with low-dose aspirin in the treatment of fetal growth restriction and its influence on amniotic fluid index and coagulation function of pregnant women

作　　者：王婷 刘岩 WANG Ting;LIU Yan(Yuncheng County People's Hospital,Heze 274700,China)

机构地区：[1]郓城县人民医院产科,274700

出　　处：《中国实用医药》2025年第1期15-20,共6页China Practical Medicine

摘　　要：目的探讨低分子量肝素钠与小剂量阿司匹林治疗胎儿生长受限的疗效及对孕妇羊水指数以及凝血功能的影响。方法以80例胎儿生长受限的孕妇为研究对象,以治疗方式不同作为孕妇分组依据,将其分为研究组(40例)、对照组(40例)。对照组孕妇采取常规治疗方式,研究组孕妇在常规治疗基础上加用低分子量肝素钠与小剂量阿司匹林联合治疗。比较两组孕妇治疗效果,胎儿生长发育情况,孕妇羊水指数与生物物理评分,孕妇凝血功能指标,胎儿脐动脉血流指标,新生儿结局。结果研究组治疗总有效率为97.50%,较对照组的80.00%更高,差异存在统计价值(P<0.05)。治疗后,两组胎儿双顶径、头围、股骨长度和腹围均较治疗前有所提升,且研究组胎儿双顶径(80.97±1.13)mm、头围(29.45±1.74)cm、股骨长度(58.23±1.01)mm和腹围(28.14±1.82)cm均明显大于对照组的(79.62±1.51)mm、(27.62±1.56)cm、(57.62±1.22)mm、(27.21±2.11)cm,差异存在统计价值(P<0.05)。治疗后,两组孕妇的羊水指数、生物物理评分均较治疗前有所提升,且研究组孕妇的羊水指数(13.82±1.35)cm、生物物理评分(9.86±0.14)分均明显比对照组的(11.85±1.44)cm、(9.53±0.22)分高,差异存在统计价值(P<0.05)。治疗后,两组孕妇的活化部分凝血活酶时间、凝血酶原时间均长于治疗前,D-二聚体和纤维蛋白原水平均低于治疗前,且研究组孕妇的活化部分凝血活酶时间(34.38±2.45)s、凝血酶原时间(13.16±3.21)s均长于对照组的(31.97±3.42)、(11.78±2.64)s,D-二聚体(0.95±0.32)mg/L和纤维蛋白原(2.89±1.03)g/L均低于对照组的(1.24±0.61)mg/L、(3.62±1.21)g/L,差异存在统计价值(P<0.05)。治疗后,两组胎儿脐动脉收缩末期与舒张末期峰值流速比值(S/D)、搏动指数(PI)以及阻力指数(RI)均较治疗前有所下降,且研究组胎儿脐动脉收缩末期与舒张末期峰值流速比值(2.34±0.41)、搏动指数(0.86±0.15)以及阻�Objective To explore the effect of low-molecular-weight heparin sodium combined with low-dose aspirin in the treatment of fetal growth restriction and its influence on amniotic fluid index and coagulation function of pregnant women.Methods 80 pregnant women with fetal growth restriction were selected as the research subjects,and were divided into study group(40 cases)and control group(40 cases)according to different treatment methods.The pregnant women in the control group received conventional treatment,and the pregnant women in the study group were treated with low-molecular-weight heparin sodium and low-dose aspirin.Both groups were compared in terms of therapeutic effect,fetal growth and development,amniotic fluid index and biophysical score,coagulation function index,fetal umbilical artery flow index and neonatal outcome.Results The total effective rate of the study group was 97.50%,which was higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the biparietal diameter,head circumference,femur length and abdominal circumference in both groups were improved compared with those before treatment;in the study group,the biparietal diameter was(80.97±1.13)mm,the head circumference was(29.45±1.74)cm,the femur length was(58.23±1.01)mm and the abdominal circumference was(28.14±1.82)cm,which were significantly greater than(79.62±1.51)mm,(27.62±1.56)cm,(57.62±1.22)mm and(27.21±2.11)cm in the control group;the difference was statistically significant(P<0.05).After treatment,the amniotic fluid index and biophysical score in both groups were improved compared with those before treatment;the study group had amniotic fluid index of(13.82±1.35)cm and biophysical score of(9.86±0.14)points,which were significantly higher than(11.85±1.44)cm and(9.53±0.22)points in the control group;the difference was statistically significant(P<0.05).After treatment,the activated partial thromboplastin time and prothrombin time in both groups were longer than those before tre

关 键 词：胎儿生长受限 低分子量肝素钠 羊水指数 阿司匹林 凝血功能 

分 类 号：R71[医药卫生—妇产科学]