孕前优生检查中TSH检测的应用价值分析  

Analysis of the application value of TSH detection in prenatal eugenics examination

作　　者：夏广蕊 周长磊 XIA Guang-rui;ZHOU Chang-lei(Reproductive Department,Rencheng District Maternal and Child Health Hospital,Jining 272000,China)

机构地区：[1]山东省济宁市任城区妇幼保健院生殖科,272000

出　　处：《中国实用医药》2025年第1期50-52,共3页China Practical Medicine

摘　　要：目的 分析孕前优生检查中促甲状腺激素(TSH)检测的应用价值。方法 选择接受优生检查的1816例育龄女性作为研究对象,均接受TSH检测。对比不同年龄段、体质量指数育龄女性的TSH检测异常率,对TSH异常女性开展随访,统计其妊娠及分娩结果。结果 1816例育龄女性中, TSH检测异常率为10.19%(185/1816)。40~45岁育龄女性的TSH检测异常率31.83%明显高于20~29岁的3.03%和30~39岁的9.88%, 30~39岁高于20~29岁(P<0.05)。体质量指数≥28.0 kg/m^(2)育龄女性的TSH检测异常率48.68%高于<18.5 kg/m^(2)的19.76%、18.5~23.9 kg/m^(2)的3.99%、24.0~27.9 kg/m^(2)的4.63%,<18.5 kg/m^(2)高于18.5~23.9、24.0~27.9 kg/m^(2)(P<0.05)。185例TSH异常女性中, 98例女性1年内受孕妊娠,其中10例流产, 88例顺利分娩,阴道分娩78例,剖宫产10例,不良妊娠结局发生率为10.20%(10/98)。88例产妇产后均未见严重并发症,胎儿发育正常,未见出生缺陷。结论 孕前优生检查中开展TSH检测,可明确育龄女性甲状腺功能状况,提高生育质量。Objective To analyze the application value of thyroid stimulating hormone(TSH)detection in prenatal eugenics examination.Methods A total of 1816 women of childbearing age who underwent eugenic examination were selected to receive TSH test.The abnormal rate of TSH detection in women of childbearing age with different age groups and BMI was compared,and the women with abnormal TSH were followed up to make statistics on their pregnancy and delivery results.Results Among 1816 women of childbearing age,the abnormal rate of TSH was 10.19%(185/1816).The abnormal rate of TSH in women of 40-45 years of age was 31.83%,which was significantly higher than 3.03%in women of 20-29 years of age and 9.88%in women of 30-39 years of age;the abnormal rate of TSH in women of 30-39 years of age was higher than in women of 20-29 years of age(P<0.05).The abnormal rate of TSH in women with body mass index≥28.0 kg/m^(2) was 48.68%,which was higher than that in women<18.5 kg/m^(2)(19.76%),18.5-23.9 kg/m^(2)(3.99%)and 24.0-27.9 kg/m^(2)(4.63%);the abnormal rate of TSH in women<18.5 kg/m^(2) was higher than that in women<18.5-23.9 and 24.0-27.9 kg/m^(2)(P<0.05).Among 185 women with abnormal TSH,98 women got pregnant within 1 year,including 10 cases of miscarriage,88 cases of successful delivery,78 cases of vaginal delivery,and 10 cases of cesarean section.The incidence of adverse pregnancy outcomes was 10.20%(10/98).No serious complications were found in the 88 cases.The fetus developed normally and there were no birth defects.Conclusion TSH examination in pre-pregnancy eugenic examination can clarify the thyroid function of women of childbearing age and improve the fertility quality.

关 键 词：优生检查 孕前检查 促甲状腺激素 体质量指数 

分 类 号：R71[医药卫生—妇产科学]