颈动脉粥样硬化与高血压合并OSAHS相关性研究  

Study on correlation between carotid atherosclerosis and hypertension combined with OSAHS

作　　者：刘金涛[1] 何明[1] 胡艳艳 王振 曾奋飞 李秋菊[1] LIU Jintao;HE Ming;HU Yanyan;WANG Zhen;ZENG Fenfei;LI Qiuju(Department of Cardiovascular Disease,Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing 314000,Zhejiang,China)

机构地区：[1]嘉兴市中医医院心血管病科,浙江嘉兴314001

出　　处：《中国现代医生》2025年第2期5-8,共4页China Modern Doctor

基　　金：国家中医药管理局方水林全国名老中医药专家传承工作室(人教发[2016]42号);第二批嘉兴市中医药重点学科支撑类项目(中医内科学)(嘉卫[2023]65号-3)。

摘　　要：目的研究颈动脉中内膜厚度(intima-media thickness,IMT)在高血压合并阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者中的水平,分析高血压合并OSAHS与IMT的关系,探讨IMT与高血压合并OSAHS患者发生风险的相关性。方法选择嘉兴市中医医院2020年1月至2024年2月收治的高血压合并OSAHS患者50例作为观察组,单纯高血压患者50例作为对照组,收集两组患者呼吸紊乱指数(apnea hyponea index,AHI)、夜间最低血氧饱和度(lowest oxygen saturatio,L-SaO_(2))、夜间平均血氧饱和度(mean oxygen saturatio,M-SaO_(2))、动态血压24h、白天和夜间平均收缩压和平均舒张压、IMT,比较两组间IMT与高血压合并OSAHS严重程度的相关性。结果与对照组比较,观察组患者AHI、IMT平均收缩压和平均舒张压升高,L-SaO_(2)、M-SaO_(2)降低(P<0.01)。观察组患者AHI与平均收缩压和平均舒张压呈正相关,L-SaO_(2)与24h平均收缩压和白天平均收缩压呈负相关(P<0.05)。观察组患者AHI与IMT呈正相关,L-SaO_(2)、M-SaO_(2)与IMT呈负相关(P<0.01)。结论高血压合并OSAHS患者疾病的严重程度与患者血压水平和IMT的变化密切相关,积极控制血压和IMT可能有助于改善患者预后,降低心血管事件发生,对指导治疗方法和预后评价具有一定的临床价值。Objective To analyze the relationship between hypertension combined with obstructive sleep apnea hypopnea syndrome(OSAHS)and intima-media thickness(IMT)and explore the correlation between the risk of IMT and hypertension with OSAHS patients.Methods Select 50 patients with hypertension and OSAHS patients who were treated in Jiaxing Hospital of Traditional Chinese Medicine during January 2020 to February 2024 as observation group,while 50 patients with simple hypertension were used as control groups to collect two groups of patients’sleep respiratory monitoring disorders(AHI),lowest blood oxygen saturation(L-SaO_(2))at night,average hemodium oxygen saturation(M-SaO_(2))at night,dynamic blood pressure 24h,daytime and night’s average diastolic blood pressure,IMT,conducting relevant statistical analysis,compares correlation between IMT of two groups and the severity of OSAHS.Results Compared with control group,observation group AHI,IMT,average systolic blood pressure voltage and average diastolic blood pressure increased significantly(P<0.01),L-SaO_(2),M-SaO_(2)decreased significantly(P<0.01).Observation group AHI and average systolic blood voltage and average diastolic pressure of average systolic blood pressure at 24h,daytime,and night were positively correlated(P<0.01),L-SaO_(2),24h and daytime average contraction pressure were negatively correlated(P<0.05).Observation group AHI and IMT were positive,and L-SaO_(2),M-SaO_(2)and IMT were negatively related(P<0.01).Conclusion Severity of the disease of hypertension combined with OSAHS patients is closely related to patient’s blood pressure level and change of IMT.Actively controlling blood pressure and IMT may help improve prognosis of patients,reduce the occurrence of cardiovascular events.The prognostic evaluation has certain clinical value.

关 键 词：高血压 阻塞性睡眠呼吸暂停低通气综合征 呼吸紊乱指数 颈动脉中内膜厚度 

分 类 号：R544.1[医药卫生—心血管疾病]